Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/58731
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Brito, A. | por |
dc.contributor.author | Abul-Haija, Y. M. | por |
dc.contributor.author | Soares da Costa, D. | por |
dc.contributor.author | Novoa-Carballal, Ramon | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Ulijn, R. V. | por |
dc.contributor.author | Pires, R. A. | por |
dc.contributor.author | Pashkuleva, I. | por |
dc.date.accessioned | 2019-01-30T10:53:39Z | - |
dc.date.available | 2019-01-30T10:53:39Z | - |
dc.date.issued | 2019 | - |
dc.date.submitted | 2019-01 | - |
dc.identifier.citation | Brito A., Abul-Haija Y. M., Soares da Costa D., Novoa-Carballal R., Reis R. L., Ulijn R. V., Pires R. A., Pashkuleva I. Minimalistic supramolecular proteoglycan mimics by co-assembly of aromatic peptide and carbohydrate amphiphiles, Chemical Science, doi: 10.1039/c8sc04361b, 2018 | por |
dc.identifier.issn | 2041-6520 | por |
dc.identifier.uri | https://hdl.handle.net/1822/58731 | - |
dc.description.abstract | We report the co-assembly of aromatic carbohydrate and dipeptide amphiphiles under physiological conditions as a strategy to generate minimalistic proteoglycan mimics. The resulting nanofibers present a structural, fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) core and a functional carbohydrate (Fmoc-glucosamine-6-sulfate or -phosphate) shell. The size, degree of bundling and mechanical properties of the assembled structures depend on the chemical nature of the carbohydrate amphiphile used. In cell culture medium, these nanofibers can further organize into supramolecular hydrogels. We demonstrate that, similar to proteoglycans, the assembled gels prolong the stability of growth factors and preserve the viability of cultured cells. Our results demonstrate that this approach can be applied to the design of extracellular matrix (ECM) substitutes for future regenerative therapies. | por |
dc.description.sponsorship | We acknowledge the EU's H2020 and FP7 framework programmes (Forecast 668983; CHEM2NATURE 692333; THE DISCOVERIES CTR 739572; ERC AdG ComplexiTE 321266) and the Portuguese FCT (IF/00032/2013; BD/113794/2015; BPD/85790/2012; M-ERA-NET2/0001/2016 – INCIPIT; ENMed/001/2015 – CytoNanoHeal). We thank P. Frederix for his help in the FTIR measurements and M. Mullin for her help in the TEM imaging. | por |
dc.language.iso | eng | por |
dc.publisher | Royal Society of Chemistry | por |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/668983/EU | por |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/692333/EU | por |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/664559/EU | por |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/321266/EU | por |
dc.relation | BD/113794/2015 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F85790%2F2012/PT | por |
dc.rights | openAccess | por |
dc.subject | co-assembly | por |
dc.subject | proteoglycans | por |
dc.subject | self-assembly | por |
dc.subject | supramolecular gels | por |
dc.subject | supramolecular systems | por |
dc.title | Minimalistic supramolecular proteoglycan mimics by co-assembly of aromatic peptide and carbohydrate amphiphiles | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://pubs.rsc.org/en/content/articlepdf/2019/sc/c8sc04361b | por |
dc.comments | http://3bs.uminho.pt/node/19695 | por |
oaire.citationStartPage | 2385 | por |
oaire.citationEndPage | 2390 | por |
oaire.citationIssue | 8 | por |
oaire.citationVolume | 10 | por |
dc.date.updated | 2019-01-30T09:50:04Z | - |
dc.identifier.doi | 10.1039/c8sc04361b | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Chemical Science | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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19695-Brito et al_ChemSci_2019.pdf | 1,12 MB | Adobe PDF | Ver/Abrir |