Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/56325
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Campo DC | Valor | Idioma |
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dc.contributor.author | Kumar, B. N. P. | por |
dc.contributor.author | Puvvada, N. | por |
dc.contributor.author | Rajput, S. | por |
dc.contributor.author | Sarkar, S. | por |
dc.contributor.author | Mahto, K. | por |
dc.contributor.author | Yallapu, M. | por |
dc.contributor.author | Pathak, A. | por |
dc.contributor.author | Emdad, L. | por |
dc.contributor.author | Das, S. K. | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Kundu, Subhas C | por |
dc.contributor.author | Fisher, B. | por |
dc.contributor.author | Mandal, M. | por |
dc.date.accessioned | 2018-10-18T09:42:57Z | - |
dc.date.issued | 2018-07 | - |
dc.date.submitted | 2018-09 | - |
dc.identifier.citation | Kumar B. N. P., Puvvada N., Rajput S., Sarkar S., Mahto K., Yallapu M., Pathak A., Emdad L., Das S. K., Reis R. L., Kundu S. C., Fisher B., Mandal M. Targeting of EGFR, VEGFR2 and Akt by engineered dual drug encapsulated mesoporous silica-gold nanoclusters sensitizes tamoxifen-resistant breast cancer, ACS Molecular Pharmaceutics, Vol. 15, Issue 7, pp. 2698–2713, doi:10.1021/acs.molpharmaceut.8b00218, 2018 | por |
dc.identifier.issn | 1543-8384 | por |
dc.identifier.uri | https://hdl.handle.net/1822/56325 | - |
dc.description.abstract | Tamoxifen administration enhanced overall disease-free survival and diminished mortality rates in cancer patients. However, patients with breast cancer often fail to respond for tamoxifen therapy due to the development of a drug-resistant phenotype. Functional analysis and molecular studies suggest that protein mutation and dysregulation of survival signaling molecules such as epidermal growth factor receptor, vascular endothelial growth factor receptor 2, and Akt contribute to tamoxifen resistance. Various strategies, including combinatorial therapies, show chemosensitize tamoxifen-resistant cancers. Based on chemotoxicity issues, researchers are actively investigating alternative therapeutic strategies. In the current study, we fabricate a mesoporous silica gold cluster nanodrug delivery system that displays exceptional tumor-targeting capability, thus promoting accretion of drug indices at the tumor site. We employ dual drugs, ZD6474, and epigallocatechin gallate (EGCG) that inhibit EGFR2, VEGFR2, and Akt signaling pathways since changes in these signaling pathways confer tamoxifen resistance in MCF 7 and T-47D cells. Mesoporous silica gold cluster nanodrug delivery of ZD6474 and EGCG sensitize tamoxifen-resistant cells to apoptosis. Western and immune-histochemical analyses confirmed the apoptotic inducing properties of the nanoformulation. Overall, results with these silica gold nanoclusters suggest that they may be a potent nanoformulation against chemoresistant cancers. | por |
dc.description.sponsorship | B.N.P.K. and S.R. are the research fellowship recipients from the Council of Scientific and Industrial Research (CSIR), India. N.P. is the recipient of DST-Inspire faculty program (GAP0631). P.B.F. holds the Thelma Newmeyer Corman Chair in Cancer Research at the VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA USA. S.C.K. holds ERA Chair Professor of European Commission Programme (FoReCaST- grant number 668983) at 3Bs Research Group University of Minho, Portugal. This work was supported by Council of Scientific and Industrial Research (CSIR), Department of Biotechnology (DBT) and Department of Science and Technology (DST), India. | por |
dc.language.iso | eng | por |
dc.publisher | ACS | por |
dc.rights | restrictedAccess | por |
dc.subject | Akt | por |
dc.subject | EGFR | por |
dc.subject | epigallocatechin gallate | por |
dc.subject | silica-gold nanoclusters | por |
dc.subject | VEGFR2 | por |
dc.subject | ZD6474 | por |
dc.title | Targeting of EGFR, VEGFR2 and Akt by engineered dual drug encapsulated mesoporous silica-gold nanoclusters sensitizes tamoxifen-resistant breast cancer | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b00218 | por |
dc.comments | http://3bs.uminho.pt/node/19627 | por |
oaire.citationStartPage | 2698–2713 | por |
oaire.citationEndPage | 2713 | por |
oaire.citationIssue | 7 | por |
oaire.citationVolume | 15 | por |
dc.date.updated | 2018-10-17T15:08:34Z | - |
dc.identifier.doi | 10.1021/acs.molpharmaceut.8b00218 | por |
dc.identifier.pmid | 29787277 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Molecular Pharmaceutics | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
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19627-Kumar_et_al_2018_acs_mol_pharmaceut.pdf Acesso restrito! | 5,08 MB | Adobe PDF | Ver/Abrir |