Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/55082
Título: | Ultrasound-assisted biosynthesis of novel methotrexate-conjugates |
Autor(es): | Noro, Jennifer Martins Reis, R. L. Cavaco-Paulo, Artur Silva, Carla |
Palavras-chave: | Biosynthesis Lipases Ultrasound Methotrexate triacylglycerols cyclodextrins |
Data: | Nov-2018 |
Editora: | Elsevier 1 |
Revista: | Ultrasonics Sonochemistry |
Citação: | Jennifer Noro; Reis, Rui L.; Cavaco-Paulo, Artur; Silva, Carla, Ultrasound-assisted biosynthesis of novel methotrexate-conjugates. Ultrasonics Sonochemistry, 48, 51-56, 2018 |
Resumo(s): | New methotrexate-acylglycerols and methotrexate-cyclodextrins (, and -CD) conjugates were obtained via esterification or transesterification reactions. All reactions were catalysed by esterases namely immobilized Lipase from Candida antarctica B and Lipase from Thermomyces lanuginosus. The use of ultrasound to assist the reactions revealed to be a key factor to obtain high conversion yields on both MTX conjugates. Transesterification reactions including long chain triacylglycerols were only successful when ultrasound was applied. In cyclodextrins esterification a higher number of MTX molecules was also linked to cyclodextrins when ultrasound was used. All the conjugates were characterized by MALDI-TOF and NMR spectroscopy. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/55082 |
DOI: | 10.1016/j.ultsonch.2018.05.017 |
ISSN: | 1350-4177 |
e-ISSN: | 1350-4177 |
Versão da editora: | http://www.journals.elsevier.com/ultrasonics-sonochemistry/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_47703_1.pdf | 641,69 kB | Adobe PDF | Ver/Abrir |