Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/55082
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Campo DC | Valor | Idioma |
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dc.contributor.author | Noro, Jennifer Martins | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Cavaco-Paulo, Artur | por |
dc.contributor.author | Silva, Carla | por |
dc.date.accessioned | 2018-06-19T08:57:44Z | - |
dc.date.available | 2018-06-19T08:57:44Z | - |
dc.date.issued | 2018-11 | - |
dc.identifier.citation | Jennifer Noro; Reis, Rui L.; Cavaco-Paulo, Artur; Silva, Carla, Ultrasound-assisted biosynthesis of novel methotrexate-conjugates. Ultrasonics Sonochemistry, 48, 51-56, 2018 | por |
dc.identifier.issn | 1350-4177 | por |
dc.identifier.uri | https://hdl.handle.net/1822/55082 | - |
dc.description.abstract | New methotrexate-acylglycerols and methotrexate-cyclodextrins (, and -CD) conjugates were obtained via esterification or transesterification reactions. All reactions were catalysed by esterases namely immobilized Lipase from Candida antarctica B and Lipase from Thermomyces lanuginosus. The use of ultrasound to assist the reactions revealed to be a key factor to obtain high conversion yields on both MTX conjugates. Transesterification reactions including long chain triacylglycerols were only successful when ultrasound was applied. In cyclodextrins esterification a higher number of MTX molecules was also linked to cyclodextrins when ultrasound was used. All the conjugates were characterized by MALDI-TOF and NMR spectroscopy. | por |
dc.description.sponsorship | This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684) and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by European Regional Development Fund under the scope of Norte2020 – Programa Operacional Regional do Norte. Jennifer Noro also thanks to FCT – Fundação para a Ciência e a Tecnologia for funding her scholarship (SFRH/BD/121673/2016). This work has also received funding from the European Union Horizon 2020 research and innovation programme under grant agreement NMP-06-2015-683356 FOLSMART. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147337/PT | por |
dc.relation | SFRH/BD/121673/2016 | por |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/683356/EU | por |
dc.rights | openAccess | por |
dc.subject | Biosynthesis | por |
dc.subject | Lipases | por |
dc.subject | Ultrasound | por |
dc.subject | Methotrexate | por |
dc.subject | triacylglycerols | por |
dc.subject | cyclodextrins | por |
dc.title | Ultrasound-assisted biosynthesis of novel methotrexate-conjugates | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.journals.elsevier.com/ultrasonics-sonochemistry/ | por |
dc.comments | CEB47703 | por |
dc.comments | http://3bs.uminho.pt/node/19735 | - |
oaire.citationStartPage | 51 | por |
oaire.citationEndPage | 56 | por |
oaire.citationConferencePlace | Netherlands | - |
oaire.citationVolume | 48 | por |
dc.date.updated | 2018-05-26T15:58:04Z | - |
dc.identifier.eissn | 1350-4177 | por |
dc.identifier.doi | 10.1016/j.ultsonch.2018.05.017 | por |
dc.identifier.pmid | 30080579 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Ultrasonics Sonochemistry | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_47703_1.pdf | 641,69 kB | Adobe PDF | Ver/Abrir |