Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/48102
Título: | Synthesis of N-alkyl-C α, α-dimethylglycine derivatives |
Autor(es): | Monteiro, Luís S. Pereira-Lima, Sílvia M. M. A. Pereira, Sofia Machado, João N |
Palavras-chave: | Amino acids nonnatural amino acids alkylation N-alkyl-Calpha alpha-dimethylglycines |
Data: | 2014 |
Editora: | ARKAT USA, Inc. |
Revista: | Arkivoc |
Citação: | Luís S. Monteiro, Silvia M. M. A. Pereira-Lima, Sofia Pereira, and João N. Machado, ARKIVOC 2014 (v) 170-180 |
Resumo(s): | The application of trialkyloxonium tetrafluoroborates for N-alkylation of the nonnatural amino acid Cα, α-dimethylglycine is described. Several methyl esters of dimethylglycine protected with different amine protecting groups were subject to N-ethylation or N-methylation with triethyloxonium tetrafluoroborate or trimethyloxonium tetrafluoroborate, respectively. The corresponding N-akyl-Cα, α-dimethylglycine derivatives were obtained in good to high yields. Removal of the methyl ester rendered amino acid derivatives ready for application in peptide synthesis. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/48102 |
DOI: | 10.3998/ark.5550190.p008.622 |
ISSN: | 1551-7012 |
e-ISSN: | 1551-7004 |
Versão da editora: | http://www.arkat-usa.org/get-file/51110 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
2014-Arkivoc 170.pdf | 117,25 kB | Adobe PDF | Ver/Abrir |