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https://hdl.handle.net/1822/45412Registo completo
| Campo DC | Valor | Idioma |
|---|---|---|
| dc.contributor.author | Santos, L. | por |
| dc.contributor.author | Silva, M. | por |
| dc.contributor.author | Gonçalves, Ana I. | por |
| dc.contributor.author | Pesqueira, T. | por |
| dc.contributor.author | Rodrigues, Márcia T. | por |
| dc.contributor.author | Gomes, Manuela E. | por |
| dc.date.accessioned | 2017-04-21T15:34:41Z | - |
| dc.date.issued | 2016-04 | - |
| dc.date.submitted | 2016-04 | - |
| dc.identifier.citation | Santos L., Silva M., Gonçalves A. I., Pesqueira T., Rodrigues M. T., Gomes M. E. In vitro and in vivo assessment of magnetically actuated biomaterials and prospects in tendon healing, Nanomedicine, Issue Revolutionising Healthcare, pp. 1, doi:10.2217/nnm-2015-0014, 2016 | por |
| dc.identifier.issn | 1743-5889 | por |
| dc.identifier.uri | https://hdl.handle.net/1822/45412 | - |
| dc.description.abstract | Aim: To expand our understanding on the effect of magnetically actuated biomaterials in stem cells, inflammation and fibrous tissue growth. Materials & methods: Magnetic biomaterials were obtained by doping iron oxide particles into starch poly-ϵ-caprolactone (SPCL) to create two formulations, magSPCL-1.8 and 3.6. Stem cell behavior was assessed in vitro and the inflammatory response, subcutaneously in Wistar rats. Results: Metabolic activity and proliferation increased significantly overtime in SPCL and magSPCL-1.8. Electromagnetic fields attenuated the presence of mast cells and macrophages in tissues surrounding SPCL and magSPCL-1.8, between weeks 1 and 9. Macrophage reduction was more pronounced for magSPCL-1.8, which could explain why this material prevented growth of fibrous tissue overtime. Conclusion: Magnetically actuated biomaterials have potential to modulate inflammation and the growth of fibrous tissue. | por |
| dc.description.sponsorship | This work was supported by POLARIS funded under FP7-REPGOT and Incentivo/SAU/LA0026/2014 from the Foundation for Science and Technology. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. | por |
| dc.language.iso | eng | por |
| dc.publisher | Future Medicine | por |
| dc.relation | info:eu-repo/grantAgreement/EC/FP7/316331/EU | por |
| dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/137390/PT | por |
| dc.rights | restrictedAccess | por |
| dc.subject | Fibrous adhesions | por |
| dc.subject | Magnetic biomaterials | por |
| dc.subject | Tendon healing/repair | por |
| dc.subject | electromagnetic fields | por |
| dc.subject | magnetic responsive biomaterials | por |
| dc.subject | regenerative medicine | por |
| dc.title | In vitro and in vivo assessment of magnetically actuated biomaterials and prospects in tendon healing | por |
| dc.type | article | - |
| dc.peerreviewed | yes | por |
| dc.relation.publisherversion | http://www.futuremedicine.com/doi/abs/10.2217/nnm-2015-0014 | por |
| dc.comments | http://3bs.uminho.pt/node/18714 | por |
| sdum.publicationstatus | info:eu-repo/semantics/publishedVersion | por |
| oaire.citationStartPage | 1 | por |
| oaire.citationEndPage | 1122 | por |
| oaire.citationIssue | Revolutionising Healthcare | por |
| oaire.citationTitle | Nanomedicine | por |
| oaire.citationVolume | 11 | por |
| dc.date.updated | 2016-04-27T15:09:26Z | - |
| dc.identifier.doi | 10.2217/nnm-2015-0014 | por |
| dc.identifier.pmid | 27078784 | por |
| dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | por |
| dc.subject.wos | Science & Technology | por |
| sdum.journal | Nanomedicine | por |
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Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| 18714_LSantos.pdf Acesso restrito! | 10,73 MB | Adobe PDF | Ver/Abrir |
