Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/40312
Título: | Polysaccharide-based freestanding multilayered membranes exhibiting reversible switchable properties |
Autor(es): | Silva, Joana M. Caridade, S. G. Reis, R. L. Mano, J. F. |
Palavras-chave: | Biomaterials Calcium-induced adhesion Dynamic mechanical analysis Layer-by-layer Nanobiomaterials Shape-memory |
Data: | 2016 |
Editora: | Royal Society of Chemistry |
Revista: | Soft Matter |
Citação: | Silva J. M., Caridade S. G., Reis R. L., Mano J. F. Polysaccharide-based freestanding multilayered membranes exhibiting reversible switchable properties, Soft Matter, doi:10.1039/C5SM02458G, 2016. |
Resumo(s): | The design of self-standing multilayered structures based on biopolymers has been attracting increasing interest due to their potential in the biomedical field. However, their use has been limited due to their gel-like properties. Herein, we report the combination of covalent and ionic cross-linking, using natural and non-cytotoxic cross-linkers, such as genipin and calcium chloride (CaCl2). Combining both cross-linking types the mechanical properties of the multilayers increased and the water uptake ability decreased. The ionic cross-linking of multilayered chitosan (CHI)â alginate (ALG) films led to freestanding membranes with multiple interesting properties, such as: improved mechanical strength, calcium-induced adhesion and shape memory ability. The use of CaCl2 also offered the possibility of reversibly switching all of these properties by simple immersion in a chelate solution. We attribute the switch-ability of the mechanical properties, shape memory ability and the propensity for induced-adhesion to the ionic cross-linking of the multilayers. These findings suggested the potential of the developed polysaccharide freestanding membranes in a plethora of research fields, including in biomedical and biotechnological fields. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/40312 |
DOI: | 10.1039/C5SM02458G |
ISSN: | 1744-683X |
Versão da editora: | http://pubs.rsc.org/en/content/articlelanding/2016/sm/c5sm02458g#!divAbstract |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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18638-Soft Matter.pdf Acesso restrito! | 3,08 MB | Adobe PDF | Ver/Abrir |