Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/38634

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dc.contributor.authorCosta, Rui R.por
dc.contributor.authorCosta, A. M. S.por
dc.contributor.authorCaridade, S. G.por
dc.contributor.authorMano, J. F.por
dc.date.accessioned2015-12-02T17:53:34Z-
dc.date.issued2015-10-
dc.date.submitted2015-09-
dc.identifier.citationCosta R. R., Costa A. M. S., Caridade S. G., Mano J. F. Compact Saloplastic Membranes of Natural Polysaccharides for Soft Tissue Engineering, Chemistry of Materials, Vol. 27, Issue 21, pp. 7490-7502, doi:10.1021/acs.chemmater.5b03648, 2015por
dc.identifier.issn0897-4756por
dc.identifier.issn1520-5002por
dc.identifier.urihttp://hdl.handle.net/1822/38634-
dc.description.abstractThe regeneration of soft biological tissues requires new substitutes that exhibit mechanical properties similar to the native tissue. Herein, thin saloplastic membranes with tunable physical properties are prepared by complexation of chitosan and alginate solutions containing different concentrations of sodium chloride. Polyelectrolyte complexes (PECs) are transferred to flat Petri dishes for compaction into membrane shapes by sedimentation and solvent evaporation. All membranes are resistant to degradation by lysozyme and are stable in solutions with pH values between 1 and 13. Immersing the different membranes in new doping solutions of increasing salt concentrations triggers the typical saloplastic behavior, with a high water absorption and decrease of the rigidity and ultimate tensile strength. The range of such variations is tuned by the sodium chloride amount used in the synthesis: high salt concentrations increase water uptake and tensile moduli, while decreasing the ultimate strength. Cellular assays demonstrate high proliferation rates and viability of L929 fibroblasts seeded onto the most rigid membranes. The results validate the use of saloplastic membranes as soft tissue substitutes for future biomedical applications.por
dc.description.sponsorshipFundação para a Ciencia e Tecnologia (FCT, grants SFRH/BPD/95446/2013, SFRH/BD/101748/2014 and SFRH/BPD/96797/2013), “Fundo Social Europeu“(FSE) and“ Programa Operacional de Potencial Humano“ (POPH)por
dc.language.isoengpor
dc.publisherAmerican Chemical Societypor
dc.rightsrestrictedAccesspor
dc.subjectComplexationpor
dc.subjectNatural polyelectrolytespor
dc.subjectSaloplasticspor
dc.subjectSoft tissuespor
dc.titleCompact saloplastic membranes of natural polysaccharides for soft tissue engineeringpor
dc.typearticle-
dc.peerreviewedyespor
dc.relation.publisherversionhttp://pubs.acs.org/doi/abs/10.1021/acs.chemmater.5b03648por
dc.commentshttp://www.3bs.uminho.pt/node/18579por
sdum.publicationstatuspublishedpor
oaire.citationStartPage7490por
oaire.citationEndPage7502por
oaire.citationIssue21por
oaire.citationTitleChemistry of Materialspor
oaire.citationVolume27por
dc.date.updated2015-11-11T10:47:24Z-
dc.identifier.doi10.1021/acs.chemmater.5b03648por
dc.subject.fosEngenharia e Tecnologia::Biotecnologia Industrialpor
dc.subject.fosCiências Médicas::Biotecnologia Médicapor
dc.subject.wosScience & Technologypor
sdum.journalChemistry of Materialspor
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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