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https://hdl.handle.net/1822/38421
Título: | Artificial thymus: a tissue engineering strategy |
Autor(es): | Costa-Pinto, A. R. Serre-Miranda, C. Rodrigues, Bruno Cerqueira Martins, Albino Alves da Silva, Marta L. Correia-Neves, Margarida Neves, N. M. |
Palavras-chave: | Biomaterials Stem cells Thymus |
Data: | Set-2015 |
Editora: | Mary Ann Liebert |
Revista: | Tissue Engineering. Part A |
Citação: | Costa-Pinto A. R., Serre-Miranda C., Cerqueira-Rodrigues B., Martins A., Alves da Silva M. L., Correia-Neves M., Neves N. M. Artificial thymus_ a tissue engineering strategy, Tissue Engineering Part A, Vol. 21, pp. S-1-S-413, doi:10.1089/ten.tea.2015.5000.abstracts., 2015 |
Resumo(s): | The thymus is the central organ responsible for the generation of T lymphocytes (1). Various diseases cause the thymus to produce in- sufficient T cells, which can lead to immune-suppression (2). Since T cells are essential for the protection against pathogens, it is crucial to promote de novo differentiation of T cells on diseased individuals. The available clinical solutions are: 1) one protocol involving the transplant of thymic stroma from unrelated children only applicable for athymic children (3); 2) for patients with severe peripheral T cell depletion and reduced thymic activity, the administration of stimu- lating molecules stimulating the activity of the endogenous thymus (4). A scaffold (CellFoam) was suggested to support thymus regen- eration in vivo (5), although this research was discontinued. Herein, we propose an innovative strategy to generate a bioartificial thymus. We use a polycaprolactone nanofiber mesh (PCL-NFM) seeded and cultured with human thymic epithelial cells (hTECs). The cells were obtained from infant thymus collected during pediatric cardio-tho- racic surgeries. We report new data on the isolation and characterization of those cells and their interaction with PCL-NFM, by expanding hTECs into relevant numbers and by optimizing cell seeding methods. |
Tipo: | Resumo em ata de conferência |
URI: | https://hdl.handle.net/1822/38421 |
ISSN: | 1937-3341 |
Versão da editora: | http://online.liebertpub.com/doi/abs/10.1089/ten.tea.2015.5000.abstracts |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
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Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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18504-Abstracts Book.pdf Acesso restrito! | 51,1 kB | Adobe PDF | Ver/Abrir |