Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/38303

TitleTowards the design of 3D multiscale instructive tissue engineering constructs: Current approaches and trends
Author(s)Oliveira, Sara M.
Reis, R. L.
Mano, J. F.
KeywordsBiomaterials
Bottom-up
Building-blocks
Construct
Instructive
Integrative
Multiscale
Nano
Nanobiomaterials
Scaffolds
Top-down
Issue dateNov-2015
PublisherElsevier
JournalBiotechnology Advances
CitationOliveira S. M., Reis R. L., Mano J. F. Towards the Design of 3D Multiscale Instructive Tissue Engineering Constructs: Current approaches and trends, Biotechnology Advances, Vol. 33, Issue 6 Part. 1, pp. i842–855, doi:10.1016/j.biotechadv.2015.05.007, 2015
Abstract(s)The design of 3D constructs with adequate properties to instruct and guide cells both in vitro and in vivo is one of the major focuses of tissue engineering. Successful tissue regeneration depends on the favorable crosstalk between the supporting structure, the cells and the host tissue so that a balanced matrix production and degradation is achieved. Herein, the major occurring events and players in normal and regenerative tissue are overviewed. These have been inspiring the selection or synthesis of instructive cues to include into the 3D constructs. We further highlight the importance of a multiscale perception of the range of features that can be included on the biomimetic structures. Lastly, we focus on the current and developing tissue-engineering approaches for the preparation of such 3D constructs: top-down, bottom-up and integrative. Bottom-up and integrative approaches present a higher potential for the design of tissue engineering devices with multiscale features and higher biochemichal control than top-down strategies, and are the main focus of this review.
TypeArticle
URIhttps://hdl.handle.net/1822/38303
DOI10.1016/j.biotechadv.2015.05.007
ISSN0734-9750
Publisher versionhttp://www.sciencedirect.com/science/article/pii/S0734975015300069
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals


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