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TitleAlternative methodology for chitin/hydroxyapatite composites using ionic liquids and supercritical fluid technology
Author(s)Silva, Simone Santos
Duarte, Ana Rita C.
Oliveira, Joaquim M.
Mano, J. F.
Reis, R. L.
Ionic liquids
Supercritical fluid technology
scaffold pores sizing
salt leaching
controlled pore sizes
Issue dateAug-2013
JournalJournal of Bioactive and Compatible Polymers
Abstract(s)An alternative, green method was used to develop chitin-based biocomposite (ChHA) materials by an integrated strategy using ionic liquids, supercritical fluid drying, and salt leaching. ChHA matrices were produced by dissolving chitin in 1-butyl-methylimidazolium acetate along with salt and/or hydroxyapatite particles and then subsequent drying. The ChHA composite formed had a heterogeneous porous microstructure with 65%–85% porosity and pore sizes in the range of 100–300 µm. The hydroxyapatite was found to be well distributed within the composite structures and had a positive effect in the viability and proliferation of osteoblast-like cells, in vitro. Our findings indicate that these ChHA matrices have potential applications in bone tissue engineering.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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