Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/24857
Título: | Pectin-coated chitosan microgels crosslinked on superhydrophobic surfaces for 5-fluorouracil encapsulation |
Autor(es): | Puga, Ana M. Lima, A. C. Mano, J. F. Concheiro, Angel Alvarez-Lorenzo, Carmen |
Palavras-chave: | Chitosan Pectin Superhydrophobic surfaces Colorectal cancer Skin cancer pH-responsive release |
Data: | Mai-2013 |
Editora: | Elsevier 1 |
Revista: | Carbohydrate polymers |
Resumo(s): | 5-Fluorouracil(5-FU)-loaded chitosan microgels for oral and topical chemotherapy were prepared applying a superhydrophobic surface-based encapsulation technology. Drug-loaded chitosan dispersions were cross-linked and then coated with drug-free chitosan or pectin layers at the solid-air interface in a highly<br>efficient and environment-friendly way. The size of the microgels (with diameters of ca.280 and 557um for the chitosan seeds and pectin-coated microgels respectively) was the lowest obtained until now using similar biomimetic methodologies. The microgels were characterized regarding 5-FU release pro-files in vitro in aqueous media covering the pH range of the gastrointestinal tract, and cytotoxicity against two cancer cell lines sensitive to 5-FU. Owing to their control of 5-FU release in acidic medium, calcium pectinate-coated microgels can be considered as suitable for oral administration. Growth inhibition of cancer cells by 5-FU was greater when incorporated to chitosan microgels; these being potentially useful for treatment of skin and colorectal tumors. |
Tipo: | Artigo |
Descrição: | Accepted 31 May 2013 |
URI: | https://hdl.handle.net/1822/24857 |
DOI: | 10.1016/j.carbpol.2013.05.091 |
ISSN: | 0144-8617 |
Versão da editora: | http://www.sciencedirect.com/science/article/pii/S0144861713005912 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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17574-Carbohydrate Polymers_2013.pdf Acesso restrito! | 2,43 MB | Adobe PDF | Ver/Abrir |