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TitleChronic stress disrupts neural coherence between cortico-limbic structures
Author(s)Oliveira, João F.
Dias, N. S.
Correia, Mariana
Pereira, Filipa Gama
Sardinha, Vanessa Morais
Lima, Ana Raquel
Oliveira, Ana Filipa Martins
Jacinto, L. R.
Ferreira, Daniela
Silva, Ana
Reis, Joana Vanessa Santos dos
Cerqueira, João
Sousa, Nuno
KeywordsChronic stress
Power spectrum
Prefrontal cortex
Issue dateFeb-2013
PublisherFrontiers Media
JournalFrontiers in Neural Circuits
CitationOliveira JF, Dias NS, Correia M, Gama-Pereira F, Sardinha VM, Lima A, Oliveira AF, Jacinto LR, Ferreira DS, Silva AM, Reis JS, Cerqueira JJ and Sousa N (2013) Chronic stress disrupts neural coherence between cortico-limbic structures. Front. Neural Circuits 7:10. doi: 10.3389/fncir.2013.00010
Abstract(s)Chronic stress impairs cognitive function, namely on tasks that rely on the integrity of cortico-limbic networks. To unravel the functional impact of progressive stress in cortico-limbic networks we measured neural activity and spectral coherences between the ventral hippocampus (vHIP) and the medial prefrontal cortex (mPFC) in rats subjected to short term stress (STS) and chronic unpredictable stress (CUS). CUS exposure consistently disrupted the spectral coherence between both areas for a wide range of frequencies, whereas STS exposure failed to trigger such effect. The chronic stress-induced coherence decrease correlated inversely with the vHIP power spectrum, but not with the mPFC power spectrum, which supports the view that hippocampal dysfunction is the primary event after stress exposure. Importantly, we additionally show that the variations in vHIP-to-mPFC coherence and power spectrum in the vHIP correlated with stress-induced behavioral deficits in a spatial reference memory task. Altogether, these findings result in an innovative readout to measure, and follow, the functional events that underlie the stress-induced reference memory impairments.
DescriptionThe authors would like to thank Rui Gomes for the help in the application of electrophysio- logical techniques and Luís Martins and Miguel Carneiro for the histological preparations.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals
DEI - Artigos em revistas internacionais

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