Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/23953

TitleA nanotectonics approach to produce hierarchically organized bioactive glass nanoparticles-based macrospheres
Author(s)Luz, Gisela
Mano, J. F.
KeywordsBioactive glass
Mineralization
Nanoparticles
Nanotectonics
Issue dateAug-2012
PublisherRoyal Society of Chemistry
JournalNanoscale
CitationLuz G. M., Mano J. F. A nanotectonics approach to produce hierarchically organized bioactive glass nanoparticles-based macrospheres, Nanoscale, Vol. 4, pp. 6293-6297, doi:10.1039/C2NR31895D, 2012
Abstract(s)Bioactive particles have been widely used in a series of biomedical applications due to their ability to promote bone-bonding and elicit favorable biological responses in therapies associated with the replacement and regeneration of mineralized tissues. In this work hierarchical architectures are prepared by an innovative methodology using SiO2–CaO sol–gel based nanoparticles. Inspired by colloidal crystals, spherical aggregates were formed on biomimetic superhydrophobic surfaces using bioactive glass nanoparticles (BGNPs) able to promote bone regeneration. A highly ordered organization, a common feature of mineralized structures in Nature, was achieved at both nano- and microlevels, being the crystallization degree of the structures controlled by the evaporation rates taking place at room temperature (RT) or at 4 C. The crystallization degree of the structures influenced the Ca/P ratio of the apatitic film formed at their surface, after 7 days of immersion in SBF. This allows the regulation of bioactive properties and the ability to release potential additives that could be also incorporated in such particles with a high efficiency. Such a versatile method to produce bioactive particles with controlled size and internal structure could open new possibilities in designing new spherical devices for orthopaedic applications, including tissue engineering.
Typearticle
URIhttp://hdl.handle.net/1822/23953
DOI10.1039/C2NR31895D
ISSN2040-3364
Publisher versionhttp://pubs.rsc.org/en/content/articlelanding/2012/nr/c2nr31895d
Peer-Reviewedyes
AccessrestrictedAccess
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals


Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu Currículo DeGóis