Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/23762
Título: | Adhesive nanostructured multilayer films using a bacterial exopolysaccharide for biomedical applications |
Autor(es): | Costa, Rui R. Neto, Ana I. Calgeris, I. Correia, Clara R. Pinho, A. C. Marques de Fonseca, Jaime C. Öner, E. T. Mano, J. F. |
Palavras-chave: | Adhesives Biomaterials Extremophilic polymers Layer-by-layer |
Data: | Mar-2013 |
Editora: | Royal Society of Chemistry |
Revista: | Journal of Materials Chemistry B |
Resumo(s): | Medical adhesives and sealants often require that long-term adhesiveness is achieved. In this work, nanostructured coatings consisting of chitosan and the adhesive bacterial exopolysaccharide levan are fabricated using layer-by-layer (LbL) assembly. Taking advantage of the electrostatic self-assembly mechanism of LbL, the charges of both chitosan and a phosphonate-derivatized levan (Ph-levan) are measured and the feasibility to construct hybrid films is monitored and confirmed using a quartz crystal microbalance with dissipation monitoring (QCM-D). The adhesive properties between two identical bonded films with a total of 100 layers are compared to control films in which Ph-levan is replaced by alginate, revealing that the detachment force of the former is about 3 times higher than the control. Scanning electron microscopy of the films surface shows that the surface of Ph-levan films is smooth and homogeneous. Cell adhesion tests were conducted using a L929 cell line. Early cell adhesion is significantly higher in chitosan/Ph-levan films when compared to chitosan/alginate controls. These findings establish levan derivatives as bioinspired ingredients for conceiving medical adhesive devices that allow achieving enhanced mechanical and biological performance. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/23762 |
DOI: | 10.1039/c3tb20137f |
ISSN: | 2050-750X |
Versão da editora: | http://pubs.rsc.org/en/content/articlelanding/2013/TB/C3TB20137F |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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17461-o36p_RCosta_LevanLbLcoatings_JMatChemB_2013.pdf Acesso restrito! | 390,38 kB | Adobe PDF | Ver/Abrir |