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TitleAn investigation of the potential application of chitosan/aloe-based membranes for regenerative medicine
Author(s)Silva, Simone Santos
Popa, Elena Geta
Gomes, Manuela E.
Cerqueira, M. T.
Marques, A. P.
Caridade, S. G.
Teixeira, P.
Sousa, Cláudia
Mano, J. F.
Reis, R. L.
KeywordsAloe vera
Wound dressing
Aloe vera gel
Wound dressings
Dermal fibroblasts
Issue dateJun-2013
JournalActa Biomaterialia
Abstract(s)A significant number of therapeutics derived from natural polymers and plants have been developed to replace or to be used in conjunction with existing dressing products. The use of the therapeutic properties of aloe vera could be very useful in the creation of active wound dressing materials. The present work was undertaken to examine issues concerning structural features, topography, enzymatic degradation behavior, antibacterial activity and cellular response of chitosan/aloe vera-based membranes. The chitosan/aloe vera-based membranes that were developed displayed satisfactory degradation, roughness, wettability and mechanical properties. A higher antibacterial potency was displayed by the blended membranes. Moreover, in vitro assays demonstrated that these blended membranes have good cell compatibility with primary human dermal fibroblasts. The chitosan/aloe vera-based membranes might be promising wound dressing materials.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals
CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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