Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/20263

TítuloDevelopment of porous lamellar poly(L-lactic acid) scaffolds by conventional injection molding process
Autor(es)Ghosh, Satyabrata
Viana, J. C.
Reis, R. L.
Mano, J. F.
Palavras-chavePLLA
PEO
Lamellar
Scaffold
Injection molding
Data2008
EditoraElsevier 1
RevistaActa Biomaterialia
Resumo(s)A novel fabrication technique is proposed for the preparation of unidirectionally oriented, porous scaffolds by selective polymer leaching from lamellar structures created by conventional injection molding. The proof of the concept is implemented using a 50/ 50 wt.% poly(L-lactic acid)/poly(ethylene oxide) (PLLA/PEO) blend. With this composition, the PLLA and PEO blend is biphasic, containing a homogeneous PLLA/PEO phase and a PEO-rich phase. The two phases were structured using injection moldinginto welldefined alternating layers of homogeneous PLLA/PEO phase and PEO-rich phase. Leaching of water-soluble PEO from the PEO-rich phase produces macropores, and leaching of phase-separated PEO from the initially homogeneous PLLA/PEO phase produces micropores in the lamellae. Thus, scaffolds with a macroporous lamellar architecture with microporous walls can be produced. The lamellae are continuous along the flow direction, and a continuous lamellar thickness of less than 1 lm could be achieved. Porosities of 57–74% and pore sizes of around 50–100 lm can be obtained using this process. The tensile elastic moduli of the porous constructs were between 580 and 800 MPa. We propose that this organic-solvent-free method of preparing lamellar scaffolds with good mechanical properties, and the reproducibility associated with the injection moldingtechnique, holds promise for a wide range of guided tissue engineering applications.
TipoArtigo
URIhttps://hdl.handle.net/1822/20263
DOI10.1016/j.actbio.2008.03.001
ISSN1742-7061
Versão da editorahttp://www.sciencedirect.com/
Arbitragem científicayes
AcessoAcesso aberto
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
file.pdf1,4 MBAdobe PDFVer/Abrir

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID