Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/13491
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Shi, Jun | - |
dc.contributor.author | Alves, N. M. | - |
dc.contributor.author | Mano, J. F. | - |
dc.date.accessioned | 2011-09-07T16:22:06Z | - |
dc.date.available | 2011-09-07T16:22:06Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 1616-5187 | por |
dc.identifier.uri | https://hdl.handle.net/1822/13491 | - |
dc.description.abstract | A series of semi-interpenetrating, polymer network (semi-IPN), hydrogel beads, composed of calcium alginate (Ca-alginate) and poly(N-isopropylacrylamide) (PNIPAAM), were prepared for a pH/temperature-sensitive drug delivery study. The equilibrium swelling showed the independent pH- and thermo- responsive nature of the developed materials. At pH¼2.1, the release amount of indomethacin incorporated into these beads was about 10% within 400 min, while this value approached to 95% at pH¼7.4. The release rate of the drug was higher at 37 8Cthan that at 25 8C and increased slightly with increasing PNIPAAM content. These results suggest that the Caalginate/ PNIPAAM beads have the potential to be used as an effective pH/temperature sustainable delivery system of bioactive agents. | por |
dc.language.iso | eng | por |
dc.publisher | Wiley-Blackwell | por |
dc.rights | openAccess | por |
dc.subject | Alginate | por |
dc.subject | Biomaterials | por |
dc.subject | Drug delivery systems | por |
dc.subject | PH/temperature responsive | por |
dc.title | Drug release of pH/temperature-responsive calcium alginate/poly(N-isopropylacrylamide) semi IPN beads | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 358 | por |
oaire.citationEndPage | 363 | por |
oaire.citationIssue | 5 | por |
oaire.citationTitle | Macromolecular Bioscience | por |
oaire.citationVolume | 6 | por |
dc.identifier.doi | 10.1002/mabi.200600013 | por |
dc.identifier.pmid | 16671051 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Macromolecular Bioscience | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |