Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/12818
Título: | Optimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatite |
Autor(es): | Puppi, D. Piras, A. M. Chiellini, F. Chiellini, E. Martins, Albino Leonor, I. B. Neves, N. M. Reis, R. L. |
Palavras-chave: | electrospinning wet-spinning star polymers bisphosphonates scaffolds tissue engineering |
Data: | 2011 |
Editora: | Wiley |
Revista: | Journal of Tissue Engineering and Regenerative Medicine |
Resumo(s): | This research activity was aimed at the development of composite bioactive scaffolds made of biodegradable three-arm branched-star poly(ε-caprolactone) (∗PCL), hydroxyapatite nanoparticles (HNPs) and clodronate (CD), a bisphosphonate that has demonstrated efficacy in the treatment of various bone diseases and as an anti-inflammatory drug. During the experimental work, the processing conditions for the fabrication of fibrous meshes, by either electrospinning or wetspinning, were optimized. Stemming from a previous research activity on electrospinning of ∗PCL, ∗PCL/HNPs 3D meshes were developed, evaluating the influence of fabrication parameters on the fibres’ morphology. By exploiting the binding affinity of bisphosphonates for hydroxyapatite, a methodology was set up for obtaining a physical linkage between CD and HNPs, with the aim of having a dual bioactive system loaded into ∗PCL fibrous mats. Fibres loaded with either CD or CD–HNP particles were thus produced and analysed by scanning electron microscopy for their morphology and by energy dispersive X-ray spectroscopy for their elemental composition |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/12818 |
DOI: | 10.1002/term.310 |
ISSN: | 1932-7005 |
Versão da editora: | http://onlinelibrary.wiley.com |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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DPuppi-J Tissue Engineering and Regenerative Medicine 2011.pdf | Documento principal | 529,5 kB | Adobe PDF | Ver/Abrir |