Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/9491

TitleThe role of polysaccharide intercellular adhesin (PIA) in Staphylococcus epidermidis adhesion to host tissues and subsequent antibiotic tolerance
Author(s)Costa, A. R.
Henriques, Mariana
Oliveira, Rosário
Azeredo, Joana
Issue dateJun-2009
PublisherSpringer
JournalEuropean Journal of Clinical Microbiology & Infectious Diseases
Citation"European Journal of Clinical Microbiology & Infectious Diseases". ISSN 0934-9723. 28:6 (June 2009) 623-629.
Abstract(s)The aim of this study was to determine the role of polysaccharide intercellular adhesin (PIA) in Staphylococcus epidermidis adhesion to host tissues and subsequent antibiotic tolerance. The adherence of S. epidermidis 1457 and the mutant defective in PIA production (1457-M10) to urinary epithelium and endothelium was estimated by colony counting. Minimum bactericidal concentration and mean reduction of cellular activity (XTT) following antibiotic exposure was determined for planktonic and adhered bacteria. S. epidermidis 1457 adhered to a greater extent to both cells than the mutant strain. The adhered strains had a significantly higher antimicrobial tolerance than their planktonic counterparts. The mutant strain was, in general, the most susceptible to the antibiotics assayed. In conclusion, PIA may influence S. epidermidis adherence to host tissues and their antimicrobial susceptibility. Initial adhesion may be the main step for the acquisition of resistance in S. epidermidis.
Typearticle
URIhttp://hdl.handle.net/1822/9491
DOI10.1007/s10096-008-0684-2
ISSN0934-9723
Peer-Reviewedyes
AccessopenAccess
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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