Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/91906
Título: | Preclinical research studies for treating severe muscular injuries: focus on tissue-engineered strategies |
Autor(es): | Alheib, Omar da Silva, Lucília Pereira Reis, R. L. Correlo, V. M. Kwon, Il Keun |
Palavras-chave: | Skeletal muscle Tissue engineering in vivo preclinical skeletal muscle injuries volumetric muscle loss |
Data: | Mai-2023 |
Editora: | Cell Press |
Revista: | Trends in Biotechnology |
Citação: | Alheib O., da Silva L. P., Reis R. L., Correlo V. M. Preclinical translation of tissue-engineered strategies for severe muscular injuries, Trends In Biotechnology, Vol. 41, doi:10.1016/j.tibtech.2022.09.010, 2023 |
Resumo(s): | Severe skeletal muscle injuries are a lifelong trauma with limited medical solutions. Significant progress has been made in developing in vitro surrogates for treating such trauma. However, more attention is needed when translating these approaches to the clinic. In this review, we survey the potential of tissueengineered surrogates in promoting muscle healing, by critically analyzing data from recent preclinical models. The therapeutic advantages provided by a combination of different biomaterials, cell types, and biochemical mediators are discussed. Current therapies on muscle healing are also summarized, emphasizing their main advantages and drawbacks. We also discuss previous and ongoing clinical trials as well as highlighting future directions for the field. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/91906 |
DOI: | 10.1016/j.tibtech.2022.09.010 |
ISSN: | 0167-7799 |
Versão da editora: | https://doi.org/10.1016/j.tibtech.2022.09.010 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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21187-34-2022-oa.pdf Acesso restrito! | 3,61 MB | Adobe PDF | Ver/Abrir |