Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/9136

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dc.contributor.authorRodrigues, L. R.-
dc.contributor.authorTeixeira, J. A.-
dc.contributor.authorSchmitt, Fernando C.-
dc.contributor.authorPaulsson, Marie-
dc.contributor.authorLindmark-Mässon, Helena-
dc.date.accessioned2009-05-18T13:25:52Z-
dc.date.available2009-05-18T13:25:52Z-
dc.date.issued2009-
dc.identifier.citation"Critical Reviews in Food Science and Nutrition." ISSN 1040-8398. 49:3 (Mar. 2009) 203-217.en
dc.identifier.issn1040-8398en
dc.identifier.issn1549-7852en
dc.identifier.urihttp://hdl.handle.net/1822/9136-
dc.description.abstractLactoferrin (LF) is an iron-binding glycoprotein that is composed of the transferrin family and is predominantly found in the products of the exocrine glands located in the gateways of the digestive, respiratory, and reproductive systems, suggesting a role in the non-specific defence against invading pathogens. Additionally, several physiological roles have been attributed to LF, namely regulation of iron homeostasis, host defence against infection and inflammation, regulation of cellular growth, and differentiation and protection against cancer development and metastasis. These findings have suggested LF's great potential therapeutic use in cancer disease prevention and/or treatment, namely as a chemopreventive agent. This review looks at the recent advances in understanding the mechanisms underlying the multifunctional roles of LF and future perspectives on its potential therapeutic applications.en
dc.description.sponsorshipFundação para a Ciência e a Tecnologia (FCT) - SFRH/BPD/26064/2005.por
dc.language.isoengen
dc.publisherTaylor & Francisen
dc.rightsopenAccessen
dc.subjectLactoferrinen
dc.subjectChemopreventionen
dc.subjectInfectionen
dc.subjectInflammationen
dc.subjectCanceren
dc.titleLactoferrin and cancer disease preventionen
dc.typearticlepor
dc.peerreviewedyesen
dc.relation.publisherversionhttp://www.informaworld.com/smpp/home~db=allen
sdum.number3en
sdum.pagination203-217en
sdum.publicationstatuspublisheden
sdum.volume49en
oaire.citationStartPage203por
oaire.citationEndPage217por
oaire.citationIssue3por
oaire.citationVolume49por
dc.identifier.doi10.1080/10408390701856157por
dc.identifier.pmid19093266por
sdum.journalCritical Reviews in Food Science and Nutritionpor
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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