Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/90757| Título: | Towards engineered yeast as production platform for capsaicinoids |
| Autor(es): | Muratovska, N. Silva, P. Pozdniakova, T. A. Pereira, H. Grey, C. Johansson, Björn Carlquist, M. |
| Palavras-chave: | TRPV1 Capsaicinoids Vanillin Vanillylamine Fatty acids Acyl-CoA Capsaicin synthase Fermentation Capsicum Saccharomyces cerevisiae |
| Data: | Out-2022 |
| Editora: | Elsevier 1 |
| Revista: | Biotechnology Advances |
| Citação: | Muratovska, N., Silva, P., Pozdniakova, T., Pereira, H., Grey, C., Johansson, B., & Carlquist, M. (2022, October). Towards engineered yeast as production platform for capsaicinoids. Biotechnology Advances. Elsevier BV. http://doi.org/10.1016/j.biotechadv.2022.107989 |
| Resumo(s): | Capsaicinoids are bioactive alkaloids produced by the chili pepper fruit and are known to be the most potent agonists of the human pain receptor TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1). They are currently produced by extraction from chili pepper fruit or by chemical synthesis. Transfer of the biosynthetic route to a microbial host could enable more efficient capsaicinoid production by fermentation and may also enable the use of synthetic biology to create a diversity of new compounds with potentially improved properties. This review summarises the current state of the art on the biosynthesis of capsaicinoid precursors in baker's yeast, Saccharomyces cerevisiae, and discusses bioengineering strategies for achieving total synthesis from sugar. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/90757 |
| DOI: | 10.1016/j.biotechadv.2022.107989 |
| ISSN: | 0734-9750 |
| e-ISSN: | 1873-1899 |
| Versão da editora: | https://www.sciencedirect.com/science/article/pii/S0734975022000854 |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
| Aparece nas coleções: | CBMA - Artigos/Papers |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Johansson B1-s2.0-S0734975022000854-main.pdf | 3,18 MB | Adobe PDF | Ver/Abrir |
