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https://hdl.handle.net/1822/89398
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Campo DC | Valor | Idioma |
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dc.contributor.author | Rodrigues, Luísa Cidália Guimarães | por |
dc.contributor.author | Ribeiro, Adriana P. | por |
dc.contributor.author | Silva, Santos S. | por |
dc.contributor.author | Reis, R. L. | por |
dc.date.accessioned | 2024-03-11T10:35:36Z | - |
dc.date.available | 2024-03-11T10:35:36Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.citation | Rodrigues L.C., Ribeiro A. P., Silva S. S., Reis R. L. Chitosan/Virgin Coconut Oil-Based Emulsions Doped with Photosensitive Curcumin Loaded Capsules: A Functional Carrier to Topical Treatment, Polymers, Vol. 16, pp. 641, doi:10.3390/polym16050641, 2024 | por |
dc.identifier.isbn | 978-3-0365-9519-1 | - |
dc.identifier.issn | 2073-4360 | por |
dc.identifier.uri | https://hdl.handle.net/1822/89398 | - |
dc.description.abstract | In recent years, there has been a growing interest in developing smart drug delivery systems based on natural resources combined with stimulus-sensitive elements. This trend aims to formulate innovative and sustainable delivery platforms tailored for topical applications. This work proposed the use of layer-by-layer (LbL) methodology to fabricate biocompatible photo-responsive multilayer systems. These systems are composed of a polyoxometalate inorganic salt (POM) ([NaP5W30O110]14â) and a natural origin polymer, chitosan (CHT). Curcumin (CUR), a natural bioactive compound, was incorporated to enhance the functionality of these systems during the formation of hollow capsules. The capsules produced, with sizes between 2â 5μm (SEM), were further dispersed into CHT/VCO (virgin coconut oil) emulsion solutions that were casted into molds and dried at 37 â ¦C for 48 h.The system presented a higher water uptake in PBS than in acidic conditions, still significantly lower than that earlier reported to other CHT/VCO-based systems. The drug release profile is not significantly influenced by the medium pH reaching a maximum of 37% ± 1% after 48 h. The antioxidant performance of the designed structures was further studied, suggesting a synergistic beneficial effect resulting from CUR, POM, and VCO individual bioactivities. The increased amount of those excipients released to the media over time promoted an increase in the antioxidant activity of the system, reaching a maximum of 38.1% ± 0.1% after 48 h. This work represents a promising step towards developing advanced, sustainable drug delivery systems for topical applications. | por |
dc.description.sponsorship | The authors would like to thank the contributions to this research from the project “TERM RES Hub–Scientific Infrastructure for Tissue Engineering and Regenerative Medicine”, reference PINFRA/22190/2016 (Norte-01-0145-FEDER-022190), funded by the Portuguese National Science Foundation (FCT) in cooperation with the Northern Portugal Regional Coordination and Development Commission (CCDR-N), for providing relevant lab facilities, state-of-the art equipment and highly qualified human resources. | por |
dc.language.iso | eng | por |
dc.publisher | MDPI | por |
dc.relation | info:eu-repo/grantAgreement/FCT/9444 - RNIIIE/PINFRA%2F22190%2F2016/PT | por |
dc.rights | openAccess | por |
dc.subject | Chitosan | por |
dc.subject | Curcumin | por |
dc.subject | Emulsion solution | por |
dc.subject | Functional drug carriers | por |
dc.subject | Natural polymers | por |
dc.subject | Virgin coconut oil | por |
dc.title | Chitosan/virgin coconut oil-based emulsions doped with photosensitive curcumin loaded capsules: a functional carrier to topical treatment | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://doi.org/10.3390/polym16050641 | por |
dc.comments | http://3bs.uminho.pt/node/21091 | por |
oaire.citationIssue | 5 | por |
oaire.citationVolume | 15 | por |
dc.date.updated | 2024-03-01T17:49:15Z | - |
dc.identifier.doi | 10.3390/polym16050641 | por |
sdum.journal | Polymers | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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21091-polymers-16-00641-1.pdf | 4,63 MB | Adobe PDF | Ver/Abrir |