Please use this identifier to cite or link to this item: https://hdl.handle.net/1822/88522

TitleCOX-2 inhibitor delivery system aiming intestinal inflammatory disorders
Author(s)Oliveira, A.
Rodrigues, L.C.
Soares da Costa, D.
Fernandes, E. M.
Reis, R. L.
Neves, N. M.
Leão, P.
Martins, Albino
KeywordsColorectal
electrospun fibrous meshes
Etoricoxib
Inflammation
Issue dateJan-2024
PublisherElsevier
JournalBiomaterials Advances
CitationOliveira, A., Rodrigues, L. C., Soares da Costa, D., Fernandes, E. M., Reis, R. L., Neves, N. M., … Martins, A. (2024, January). COX-2 inhibitor delivery system aiming intestinal inflammatory disorders. Biomaterials Advances. Elsevier BV. http://doi.org/10.1016/j.bioadv.2023.213712
Abstract(s)Selective COX-2 inhibitors such as etoricoxib (ETX) are potentially indicated for the treatment of intestinal inflammatory disorders. However, their systemic administration provokes some off-site secondary effects, decreasing the desirable local effectiveness. To circumvent such limitations, herein an ETX delivery system based on electrospun fibrous meshes (eFMs) was proposed. ETX at different concentrations (1, 2, and 3 mg mL−1) was loaded into eFMs, which not affect the morphology and the mechanical properties of this drug delivery system (DDS). The ETX showed a burst release within the first 12 h, followed by a faster release until 36 h, gradually decreasing over time. Importantly, the ETX studied concentrations were not toxic to human colonic cells (i.e. epithelial and fibroblast). Moreover, the DDS loading the highest concentration of ETX, when tested with stimulated human macrophages, promoted a reduction of PGE2, IL-8 and TNF-α secretion. Therefore, the proposed DDS may constitute a safe and efficient treatment of colorectal diseases promoted by inflammatory disorders associated with COX-2.
TypeArticle
URIhttps://hdl.handle.net/1822/88522
DOI10.1016/j.bioadv.2023.213712
ISSN2772-9508
Publisher versionhttps://www.sciencedirect.com/science/article/pii/S2772950823004351
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals
ICVS - Artigos em revistas internacionais / Papers in international journals

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