Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/87224
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Sousa, André P. | por |
dc.contributor.author | Rocha, Ana C. | por |
dc.contributor.author | Almeida, Cátia | por |
dc.contributor.author | Carneiro, Mariana C. C. G. | por |
dc.contributor.author | Pais, Patrick P. | por |
dc.contributor.author | Viana, Rejane | por |
dc.contributor.author | Fernandes, Rúben Rodrigues | por |
dc.contributor.author | Barata, Pedro | por |
dc.contributor.author | Gestoso, Álvaro | por |
dc.contributor.author | Ramalho, Susana | por |
dc.contributor.author | Martins-Mendes, Daniela | por |
dc.contributor.author | Baylina, Pilar | por |
dc.contributor.author | Pereira, Ana Cláudia | por |
dc.date.accessioned | 2023-11-14T08:42:51Z | - |
dc.date.available | 2023-11-14T08:42:51Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.citation | Sousa, A.P.; Rocha, A.C.; Almeida, C.; Carneiro, M.C.C.G.; Pais, P.P.; Viana, R.; Fernandes, R.; Barata, P.; Gestoso, Á.; Ramalho, S.; et al. Moving towards Personalized Medicine—The Broad Use of Aptamers for Targeted Theranostic. Appl. Sci. 2023, 13, 11933. https://doi.org/10.3390/app132111933 | por |
dc.identifier.issn | 2076-3417 | por |
dc.identifier.uri | https://hdl.handle.net/1822/87224 | - |
dc.description.abstract | Aptamers are short, single-stranded oligonucleotides synthesized in vitro from a randomized oligonucleotide library against a specific target. These molecules are capable of binding to a wide range of biological targets with high specificity and affinity. They present great advantages over antibodies with potential applications in research, diagnosis, and therapeutics. Specifically for tumors with late-stage identification and poor prognosis, like pancreatic cancer, the study of novel aptamers holds tremendous potential for cancer diagnosis and treatment. Along with cancer treatment, aptamers have also shown high potential in regulating the immune response and modulating several critical steps of signaling cascades, such as in immune checkpoints. In the context of microbiota and infection, aptamers are being studied to identify microbes and their metabolites. This assessment has the potential to improve the detection and management of infectious diseases while assisting us in better understanding health risks and treatment outcomes by tracking changes in the microbiota. In this review, the potential of aptamers is explored regarding their applications in cancer, immune, and microbiota therapy. | por |
dc.description.sponsorship | Pilar Baylina (P.B.) acknowledges on the behalf of the authors the support of Fundação para a Ciência e Tecnologia (FCT), Portuguese Government, under the Strategic Project Reference: UID/BIM/04293/2013. Pilar Baylina (P.B.) and R.F. was also supported by FEDER/02/SAICT/2020/072560. Ana Cláudia Pereira (A.C.P.) acknowledges the support of Fundação para a Ciência e Tecnologia (FCT), Portuguese Government, under the Strategic Project Reference: 2022.09032.PTDC. André P. Sousa acknowledges FCT for the PhD grant 2022.12441.BD. Ana C. Rocha acknowledges FCT for the PhD grant 2021.06521.BD. Patrick P. Pais acknowledges FCT for the PhD grant 2021.09498.BD. Susana Ramalho acknowledges LaBMI for the PhD grant LABMI/BI/2021/01 (NEURO4COVID). | por |
dc.language.iso | eng | por |
dc.publisher | MDPI | por |
dc.relation | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FBIM%2F04293%2F2013/PT | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POR_NORTE/2021.06521.BD/PT | por |
dc.relation | 2021.09498.BD | por |
dc.relation.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.rights | openAccess | por |
dc.subject | Aptamer | por |
dc.subject | Cancer | por |
dc.subject | Immune response | por |
dc.subject | Microbiota | por |
dc.subject | SELEX | por |
dc.subject | Therapeutic | por |
dc.title | Moving towards personalized medicine - the broad use of aptamers for targeted theranostic | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2076-3417/13/21/11933 | por |
dc.comments | CEB56508 | por |
oaire.citationStartPage | 11933 | por |
oaire.citationIssue | 21 | por |
oaire.citationConferencePlace | Switzerland | - |
oaire.citationVolume | 13 | por |
dc.date.updated | 2023-11-13T20:30:18Z | - |
dc.identifier.doi | 10.3390/app132111933 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
sdum.journal | Applied Sciences | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
document_56508_1.pdf | 706,47 kB | Adobe PDF | Ver/Abrir |