Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/85467
Título: | Silk fibroin microneedles for transdermal drug delivery: where do we stand and how far can we proceed? |
Autor(es): | Qi, Zhenzhen Yan, Zheng Tan, Guohongfang Jia, Tianshuo Geng, Yiyu Shao, Huiyan Kundu, Subhas C Lu, Shenzhou |
Palavras-chave: | Silk fibroin microneedles Transdermal delivery Intelligently responsive Clinical transformation |
Data: | 20-Jan-2023 |
Editora: | Multidisciplinary Digital Publishing Institute (MDPI) |
Revista: | Pharmaceutics |
Citação: | Qi, Z.; Yan, Z.; Tan, G.; Jia, T.; Geng, Y.; Shao, H.; Kundu, S.C.; Lu, S. Silk Fibroin Microneedles for Transdermal Drug Delivery: Where Do We Stand and How Far Can We Proceed? Pharmaceutics 2023, 15, 355. https://doi.org/10.3390/pharmaceutics15020355 |
Resumo(s): | Microneedles are a patient-friendly technique for delivering drugs to the site of action in place of traditional oral and injectable administration. Silk fibroin represents an interesting polymeric biomaterial because of its mechanical properties, thermal stability, biocompatibility and possibility of control via genetic engineering. This review focuses on the critical research progress of silk fibroin microneedles since their inception, analyzes in detail the structure and properties of silk fibroin, the types of silk fibroin microneedles, drug delivery applications and clinical trials, and summarizes the future development trend in this field. It also proposes the future research direction of silk fibroin microneedles, including increasing drug loading doses and enriching drug loading types as well as exploring silk fibroin microneedles with stimulation-responsive drug release functions. The safety and effectiveness of silk fibroin microneedles should be further verified in clinical trials at different stages. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/85467 |
DOI: | 10.3390/pharmaceutics15020355 |
e-ISSN: | 1999-4923 |
Versão da editora: | https://www.mdpi.com/1999-4923/15/2/355 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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pharmaceutics-15-00355.pdf | 4,9 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons