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TitleAddressing the challenges with bacterial vaginosis pharmacotherapy
Author(s)Cerca, Nuno
KeywordsBacterial vaginosis
recurrent infection
multi-species biofilm
Issue date2023
PublisherTaylor & Francis
JournalExpert Opinion on Pharmacotherapy
CitationCerca, Nuno, Addressing the challenges with bacterial vaginosis pharmacotherapy. Expert Opinion on Pharmacotherapy, 24(1), 11-13, 2023
Abstract(s)[Excerpt] 1. Introduction: The healthy female vaginal environment is a dynamic ecosystem that is commonly colonized by several lactic acid-producing bacteria, most of the genus Lactobacillus [1]. It is believed that the normal human vaginal microbiota has an important role in maintaining health, with an impact on either baby delivery or increased risks in the acquisition of sexually transmitted infections [2]. The composition of the vaginal microbiota depends on ethnicity and can change over the menstrual cycle, during pregnancy, with age, and under external stresses, such as antimicrobial treatments [3]. For reasons not yet fully understood, the dominant healthy vagina lactic acid and hydrogen peroxide-producing lactobacilli can be replaced by a complex mixture of strictly and facultative anaerobic bacteria [4]. This significant shift in the composition of the vaginal microbiome is known as bacterial vaginosis (BV). Despite being the most common dysbiosis in women of childbearing age, BV etiology is not yet fully understood, with different controversial theories being raised over the years [3]. [...]
TypeJournal editorial
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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