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https://hdl.handle.net/1822/78355
Título: | Beyond new neurons in the adult hippocampus: imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure |
Autor(es): | Machado-Santos, Ana R. Loureiro-Campos, Eduardo Patrício, Patrícia Araújo, Bruna Alexandra Vale Alves, Nuno Dinis Mateus-Pinheiro, António Correia, Joana Sofia Silva Morais, Mónica Peixoto, João Miguel Seiça Bessa Sousa, Nuno Rodrigues, Ana João Oliveira, João F. Pinto, Luísa |
Palavras-chave: | Astrocytes Hippocampus Dentate gyrus Astrogliogenesis Chronic stress Antidepressants |
Data: | 24-Jan-2022 |
Editora: | Multidisciplinary Digital Publishing Institute (MDPI) |
Revista: | Cells |
Citação: | Machado-Santos, A.R.; Loureiro-Campos, E.; Patrício, P.; Araújo, B.; Alves, N.D.; Mateus-Pinheiro, A.; Correia, J.S.; Morais, M.; Bessa, J.M.; Sousa, N.; Rodrigues, A.J.; Oliveira, J.F.; Pinto, L. Beyond New Neurons in the Adult Hippocampus: Imipramine Acts as a Pro-Astrogliogenic Factor and Rescues Cognitive Impairments Induced by Stress Exposure. Cells 2022, 11, 390. https://doi.org/10.3390/cells11030390 |
Resumo(s): | Depression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in the pathophysiology of depression as modulators of neurotransmission and neurovascular coupling. This is evidenced by astrocyte impairments observed in brains of depressed patients and the appearance of depressive-like behaviors upon astrocytic dysfunctions in animal models. However, little is known about the importance of de novo generated astrocytes in the mammalian brain and in particular its possible involvement in the precipitation of depression and in the therapeutic actions of current antidepressants (ADs). Therefore, we studied the modulation of astrocytes and adult astrogliogenesis in the hippocampal dentate gyrus (DG) of rats exposed to an unpredictable chronic mild stress (uCMS) protocol, untreated and treated for two weeks with antidepressants—fluoxetine and imipramine. Our results show that adult astrogliogenesis in the DG is modulated by stress and imipramine. This study reveals that distinct classes of ADs impact differently in the astrogliogenic process, showing different cellular mechanisms relevant to the recovery from behavioral deficits induced by chronic stress exposure. As such, in addition to those resident, the newborn astrocytes in the hippocampal DG might also be promising therapeutic targets for future therapies in the neuropsychiatric field. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/78355 |
DOI: | 10.3390/cells11030390 |
e-ISSN: | 2073-4409 |
Versão da editora: | https://www.mdpi.com/2073-4409/11/3/390 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
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Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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cells-11-00390-v4.pdf | 2,65 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons