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https://hdl.handle.net/1822/7707
Título: | Protective role of new nitrogen compounds on ROS/RNS-mediated damage to PC12 cells |
Autor(es): | Silva, João P. Proença, M. Fernanda R. P. Coutinho, O. P. |
Palavras-chave: | lipid peroxidation oxidative stress nitrogen compounds antioxidants nitrosative stress |
Data: | 2008 |
Editora: | Informa Healthcare |
Revista: | Free Radical Research |
Citação: | "Free Radical Research". ISSN 1071-5762. 42:1 (2008) 57-69. |
Resumo(s): | Reactive oxygen (ROS) and nitrogen (RNS) species are known to be involved in many degenerative diseases. This study reports four new nitrogen compounds from organic synthesis, identified as FMA4, FMA7, FMA762 and FMA796, which differ mainly by the number of hydroxyl groups within their phenolic unit. Their potential role as antioxidants was evaluated in PC12 cells by assessing their protection against oxidative and nitrosative insults. The four compounds, and particularly FMA762 and FMA796, were able to protect cells against lipid peroxidation and intracellular ROS/RNS formation to a great extent. Their protective effects were likely mediated by their free radicals scavenging ability, as they appeared to be involved neither in the induction of natural antioxidant enzymes like GSH-PX and SOD, nor in the inhibition of NOS. Nevertheless, these results suggest a promising potential for these compounds as ROS/RNS scavengers in pathologies where oxidative/ nitrosative stress are involved. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/7707 |
DOI: | 10.1080/10715760701787719 |
ISSN: | 1071-5762 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | DBio - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Silva JP et al - Free Radic Res 2008 v42 p57.pdf | Silva JP - Free Radic Res paper | 185,4 kB | Adobe PDF | Ver/Abrir |