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https://hdl.handle.net/1822/76362
Título: | Exudative versus nonexudative age-related macular degeneration: Physiopathology and treatment options |
Autor(es): | Fernandes, Ana Rita Zielinska, Aleksandra Sanchez-Lopez, Elena dos Santos, Tiago Garcia, Maria Luisa Silva, Amelia M. Karczewski, Jacek Souto, Eliana B. |
Palavras-chave: | Age-related macular degeneration Inflammatory cascade Antiangiogenic agents Choroidal neovascularization Geographic atrophy |
Data: | 26-Fev-2022 |
Editora: | MDPI |
Revista: | International Journal of Molecular Sciences |
Citação: | Fernandes, Ana Rita; Zielinska, Aleksandra; Sanchez-Lopez, Elena; dos Santos, Tiago; Garcia, Maria Luisa; Silva, Amelia M.; Karczewski, Jacek; Souto, Eliana B., Exudative versus nonexudative age-related macular degeneration: physiopathology and treatment options. International Journal of Molecular Sciences, 23(5), 2592, 2022 |
Resumo(s): | Age-related macular degeneration (AMD) is an eye disease typically associated with the aging and can be classified into two types—namely, the exudative and the nonexudative AMD. Currently available treatments for exudative AMD use intravitreal injections, which are associated with high risk of infection that can lead to endophthalmitis, while no successful treatments yet exist for the nonexudative form of AMD. In addition to the pharmacologic therapies administered by intravitreal injection already approved by the Food and Drug Administration (FDA) in exudative AMD, there are some laser treatments approved that can be used in combination with the pharmacological therapies. In this review, we discuss the latest developments of treatment options for AMD. Relevant literature available from 1993 was used, which included original articles and reviews available in PubMed database and also information collected from Clinical Trials Gov website using “age-related macular degeneration” and “antiangiogenic therapies” as keywords. The clinical trials search was limited to ongoing trials from 2015 to date. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/76362 |
ISBN: | 1424-6783 |
DOI: | 10.3390/ijms23052592 |
ISSN: | 1422-0067 |
Versão da editora: | http://www.mdpi.com/journal/ijms |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_55325_1.pdf | 630,9 kB | Adobe PDF | Ver/Abrir |