Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/75601
Título: | Cyclodextrins-in-liposomes: a promising delivery system for Lippia sidoides and Syzygium aromaticum essential oils |
Autor(es): | Baldim, Iara Oliveira, Andressa M. Souto, Eliana Maria Barbosa Oliveira, Wanderley P. |
Palavras-chave: | Proliposomes Cyclodextrins Thymol Eugenol Lippia sidoides Syzygium aromaticum |
Data: | 10-Jan-2022 |
Editora: | Multidisciplinary Digital Publishing Institute (MDPI) |
Revista: | Life |
Citação: | Baldim, Iara; Oliveira, Andressa M.; Souto, Eliana B.; Oliveira, Wanderley P., Cyclodextrins-in-liposomes: a promising delivery system for Lippia sidoides and Syzygium aromaticum essential oils. Life, 12(1), 95, 2022 |
Resumo(s): | Biological activity of essential oils (EOs) has been extensively reported; however, their low aqueous solubility, high photosensitivity, and volatility compromise a broad industrial use of these compounds. To overcome these limitations, we proposed a nanoencapsulation approach to protect EOs, that aims to increase their stability and modulate their release profile. In this study, drug-in-cyclodextrin-in-liposomes encapsulating two essential oils (Lippia sidoides and Syzygium aromaticum) and their respective major compounds (thymol and eugenol) were produced by ethanol injection and freeze-dried to form proliposomes and further physicochemically characterized. Liposomes showed high physical stability over one month of storage at 4 °C, with slight changes in the mean size, polydispersity index (PDI), and zeta potential. Reconstituted proliposomes showed a mean size between 350 and 3300 nm, PDI from 0.29 to 0.41, and zeta potential between −22 and −26 mV. Differential scanning calorimetry and X-ray diffraction of proliposomes revealed a less-ordered crystalline structure, leading to high retention of the major bioactive compounds (between 73% and 93% for eugenol, and 74% and 84% for thymol). This work highlights the advantages of using drug-in-cyclodextrin-in-liposomes as delivery systems to retain volatile compounds, increasing their physicochemical stability and their promising potential to be utilized as carriers in products in the pharmaceutical, food, and cosmetic industries. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/75601 |
DOI: | 10.3390/life12010095 |
ISSN: | 0024-3019 |
Versão da editora: | https://www.mdpi.com/journal/life |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_55171_1.pdf | 2,91 MB | Adobe PDF | Ver/Abrir |