Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/74805
Título: | Photodynamic therapy review: principles, photosensitizers, applications, and future directions |
Autor(es): | Correia, J. H. Rodrigues, José Artur Oliveira Pimenta, Sara Filomena Ribeiro Dong, Tao Yang, Zhaochu |
Palavras-chave: | PDT mechanisms New photosensitizers PDT tumor treatment Antimicrobial PDT Non-oncologic applications of PDT PDT in medical devices |
Data: | 25-Ago-2021 |
Editora: | Multidisciplinary Digital Publishing Institute (MDPI) |
Revista: | Pharmaceutics |
Citação: | Correia, J.H.; Rodrigues, J.A.; Pimenta, S.; Dong, T.; Yang, Z. Photodynamic Therapy Review: Principles, Photosensitizers, Applications, and Future Directions. Pharmaceutics 2021, 13, 1332. https://doi.org/10.3390/pharmaceutics13091332 |
Resumo(s): | Photodynamic therapy (PDT) is a minimally invasive therapeutic modality that has gained great attention in the past years as a new therapy for cancer treatment. PDT uses photosensitizers that, after being excited by light at a specific wavelength, react with the molecular oxygen to create reactive oxygen species in the target tissue, resulting in cell death. Compared to conventional therapeutic modalities, PDT presents greater selectivity against tumor cells, due to the use of photosensitizers that are preferably localized in tumor lesions, and the precise light irradiation of these lesions. This paper presents a review of the principles, mechanisms, photosensitizers, and current applications of PDT. Moreover, the future path on the research of new photosensitizers with enhanced tumor selectivity, featuring the improvement of PDT effectiveness, has also been addressed. Finally, new applications of PDT have been covered. |
Tipo: | Artigo |
Descrição: | "This article belongs to the Special Issue: Special Issue in Honor of Dr. Michael Weber’s 70th Birthday: Photodynamic Therapy: Rising Star in Pharmaceutical Applications" |
URI: | https://hdl.handle.net/1822/74805 |
DOI: | 10.3390/pharmaceutics13091332 |
e-ISSN: | 1999-4923 |
Versão da editora: | https://www.mdpi.com/1999-4923/13/9/1332 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CMEMS - Artigos em revistas internacionais/Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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pharmaceutics-13-01332.pdf | 2,3 MB | Adobe PDF | Ver/Abrir |