Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/74468

TitleAntithrombotic and hemocompatible properties of nanostructured coatings assembled from block copolymers
Author(s)Fontelo, R.
Soares da Costa, D.
Reis, R. L.
Novoa-Carballal, Ramon
Pashkuleva, I.
KeywordsAntithrombotic
Block Copolymer
Hemocompatible
Nanopattern
Quaternization
Issue dateOct-2021
PublisherElsevier
JournalJournal of Colloid and Interface Science
CitationFontelo R., Soares da Costa D., Reis R. L., Novoa-Carballal R., Pashkuleva I. Antithrombotic and hemocompatible properties of nanostructured coatings assembled from block copolymers, Journal of Colloid and Interface Science, doi:10.1016/j.jcis.2021.10.076, 2021
Abstract(s)We describe the antithrombotic properties of nanopatterned coatings created by self-assembly of poly(styrene-block-2-vinylpyridine) (PS-b-P2VP) with different molecular weights. By changing the assembly conditions, we obtained nanopatterns that differ by their morphology (size and shape of the nanopattern) and chemistry. The surface exposition of P2VP block allowed quaternization, i.e. introduction of positive surface charge and following electrostatic deposition of heparin. Proteins (albumin and fibrinogen) adsorption, platelet adhesion and activation, cytocompatibility, and reendothelization capacity of the coatings were assessed and discussed in a function of the nanopattern morphology and chemistry. We found that quaternization results in excellent antithrombotic and hemocompatible properties comparable to heparinization by hampering the fibrinogen adhesion and platelet activation. In the case of quaternization, this effect depends on the size of the polymer blocks, while all heparinized patterns had similar performance showing that heparin surface coverage of 40 % is enough to improve substantially the hemocompatibility.
TypeArticle
URIhttp://hdl.handle.net/1822/74468
DOI10.1016/j.jcis.2021.10.076
ISSN0021-9797
Publisher versionhttps://doi.org/10.1016/j.jcis.2021.10.076
Peer-Reviewedyes
AccessEmbargoed access (1 Year)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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