Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/73930
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Moreira, Pedro | por |
dc.contributor.author | Sequeira, Ana | por |
dc.contributor.author | Pereira, S. | por |
dc.contributor.author | Rodrigues, Rúben André Costa | por |
dc.contributor.author | Rocha, Miguel | por |
dc.contributor.author | Lousa, Diana | por |
dc.date.accessioned | 2021-09-06T19:17:47Z | - |
dc.date.available | 2021-09-06T19:17:47Z | - |
dc.date.issued | 2021-08-23 | - |
dc.identifier.citation | Moreira, Pedro; Sequeira, Ana; Pereira, Sara; Rodrigues, Rúben; Rocha, Miguel; Lousa, Diana, ViralFP: a web application of viral fusion proteins. Frontiers in Medical Technology, 3(722392), 2021 | por |
dc.identifier.issn | 2673-3129 | por |
dc.identifier.uri | https://hdl.handle.net/1822/73930 | - |
dc.description.abstract | Viral fusion proteins are attached to the membrane of enveloped viruses (a group that includes Coronaviruses, Dengue, HIV and Influenza) and catalyze fusion between the viral and host membranes, enabling the virus to insert its genetic material into the host cell. Given the importance of these biomolecules, this work presents a centralized database containing the most relevant information on viral fusion proteins, available through a free-to-use web server accessible through the URL <ext-link ext-link-type=uri xlink:href=https://viralfp.bio.di.uminho.pt/ xmlns:xlink=http://www.w3.org/1999/xlink>https://viralfp.bio.di.uminho.pt/</ext-link>. This web application contains several bioinformatic tools, such as Clustal sequence alignment and Weblogo, including as well a machine learning-based tool capable of predicting the location of fusion peptides (the component of fusion proteins that inserts into the host's cell membrane) within the fusion protein sequence. Given the crucial role of these proteins in viral infection, their importance as natural targets of our immune system and their potential as therapeutic targets, this web application aims to foster our ability to fight pathogenic viruses. | por |
dc.description.sponsorship | This work was funded by COMPETE 2020, Portugal 2020 and FCT—Fundação para a Ciência e a Tecnologia, under the project Using computational and experimental methods to provide a global characterization of viral fusion peptides, through the funding program 02/SAICT/2017—Projetos de Investigação Científica e Desenvolvimento Tecnológico (IC&DT), with the reference PTDC/CCI-BIO/28200/2017. This work was also financially supported by Project LISBOA-01-0145-FEDER-007660 (Microbiologia Molecular, Estrutural e Celular) funded by FEDER funds through COMPETE2020—Programa Operacional Competitividade e Internacionalização (POCI) and by national funds through FCT—Fundação para a Ciência e a Tecnologia. | por |
dc.language.iso | eng | por |
dc.publisher | Frontiers Media S.A. | por |
dc.relation | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCCI-BIO%2F28200%2F2017/PT | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | Fusion proteins | por |
dc.subject | Fusion peptides | por |
dc.subject | Database | por |
dc.subject | Web application | por |
dc.subject | Machine learning | por |
dc.title | ViralFP: a web application of viral fusion proteins | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fmedt.2021.722392 | por |
dc.comments | CEB54609 | por |
oaire.citationIssue | 722392 | por |
oaire.citationVolume | 3 | por |
dc.date.updated | 2021-09-06T09:43:13Z | - |
dc.identifier.doi | 10.3389/fmedt.2021.722392 | por |
dc.description.publicationversion | info:eu-repo/semantics/publishedVersion | - |
sdum.journal | Frontiers in Medical Technology | por |
oaire.version | VoR | por |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54609_1.pdf | 3,4 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons