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https://hdl.handle.net/1822/73062
Título: | Synthesis of New Iminosugar Derivatives Based on (S)-(1,2,3,6-Tetrahydropyridazin-3-yl)methanol |
Autor(es): | Axundova, F. N. Kurbanova, M. M. Huseynzada, A. E. Alves, Maria José Chão |
Palavras-chave: | 1-azafagomine Boc protection Diels-Alder reaction imino sugars pyridazine S-BINOL |
Data: | 2019 |
Editora: | Pleiades Publishing |
Revista: | Russian Journal of Organic Chemistry |
Citação: | Axundova, F.N., Kurbanova, M.M., Huseynzada, A.E. et al. Synthesis of New Iminosugar Derivatives Based on (S)-(1,2,3,6-Tetrahydropyridazin-3-yl)methanol. Russ J Org Chem 55, 1975–1978 (2019). https://doi.org/10.1134/S1070428019120297 |
Resumo(s): | (S)-(1,2,3,6-Tetrahydropyridazin-3-yl)methanol was synthesized in two steps by the Diels-Alder reaction of penta-2,4-dien-1-ol with diethyl azodicarboxylate in the presence of (S)-BINOL as chiral catalyst. The subsequent Boc-protection of the 2-position of the pyridazine ring, ring-closing carbonylation of the hydroxy group, and deprotection afforded a bicyclic iminosugar analog. The structure of the isolated compounds was proved by NMR, IR, and mass spectra and elemental analyses. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/73062 |
DOI: | 10.1134/S1070428019120297 |
ISSN: | 1070-4280 |
Versão da editora: | https://link.springer.com/article/10.1134%2FS1070428019120297 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Axundova2019_Article_SynthesisOfNewIminosugarDeriva.pdf | 204,91 kB | Adobe PDF | Ver/Abrir |