Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/73000

TitleCarbohydrate amphiphiles for supramolecular biomaterials: design, self-assembly, and applications
Author(s)Brito, Alexandra Manuela Fernandes
Kassem, Salma
Reis, R. L.
Ulijn, Rein V.
Pires, R. A.
Pashkuleva, I.
KeywordsGlycoconjugate
Glycolipid
Glycopeptide
Hydrogel
Multivalency
Self-assembly
Systems chemistry
SDG3: Good health and well-being
Issue dateMay-2021
PublisherElsevier
JournalChem
CitationBrito A., Kassem S., Reis R. L., Ulijn R. V., Pires R. A., Pashkuleva I. Carbohydrate amphiphiles for supramolecular biomaterials: Design, self-assembly, and applications, Chem, Vol. 2021, doi:10.1016/j.chempr.2021.04.011, 2021
Abstract(s)Carbohydrate-containing biopolymers such as glycoproteins, proteoglycans, and glycolipids are an incredibly diverse and complex set of natural building blocks used by biological systems to endorse a wide range of molecular functions that are critical to life processes. Simplified synthetic analogs of these polymeric glycoconjugates can capture some of these functions and are increasingly exploited toward the development of supramolecular biomaterials. These carbohydrate amphiphiles can mimic structural aspects through cooperative molecular self-assembly or target distinct signaling pathways through engineered (multivalent) interactions with biological systems. Herein, we discuss the supramolecular principles that regulate the glycome function(s) and the translation of these in the design of supramolecular biomaterials in which carbohydrates are used as information-rich structural elements with huge potential as therapeutic supramolecular biomaterials.
TypeArticle
URIhttp://hdl.handle.net/1822/73000
DOI10.1016/j.chempr.2021.04.011
ISSN2451-9294
Publisher versionhttps://www.sciencedirect.com/science/article/abs/pii/S2451929421002126#!
Peer-Reviewedyes
AccessEmbargoed access (2 Years)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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