Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/72769

TitleGreen solvents combined with bioactive compounds as delivery systems: present status and future trends
Author(s)Silva, Simone S.
Gomes, Joana M.
Reis, R. L.
Kundu, Subhas C
KeywordsGreen solvents
Ionic liquids
Bioactive compounds
Synthetic compounds
Permeation enhancer
Delivery systems
Issue dateApr-2021
PublisherAmerican Chemical Society
JournalACS Applied Bio Materials
CitationSilva S. S., Gomes J. M., Reis R. L., Kundu S. C. Green Solvents Combined with Bioactive Compounds as Delivery Systems: Present Status and Future Trends, ACS Applied Bio Materials, Vol. 4, Issue 5, pp. 4000-4013, doi:10.1021/acsabm.1c00013, 2021
Abstract(s)Green solvents such as ionic liquids (ILs) unlock possibilities for developing innovative biomedical and pharmaceutical solutions. ILs are the most investigated solvents for compound extractions, as reaction media and/or catalysts, and a desired eco-friendly solvent to process biomacromolecules for biomaterial production. Investigations demonstrate that the tunable nature and physicochemical features of ILs are also beneficial for building up delivery systems through their combination with bioactive compounds. Bioactive compounds from synthetic origins, like ibuprofen, ketoprofen, and natural sources such as curcumin, flavonoids, and polyphenols are essential starting points as preventive and therapeutic agents for treating diseases. Therefore, the association of those compounds with ILs opens up windows of opportunities in this research field. This Review assesses some of the main and important recent information and the current challenges concerning delivery platforms based on ILs combined with bioactive compounds of both natural and synthetic origins. Moreover, the chemistry, bioavailability, and biological functions of the main bioactive compounds used in the ILs-based delivery platforms are described. These data are presented and are discussed, together with the main delivery routes of the systems.
TypeArticle
URIhttp://hdl.handle.net/1822/72769
DOI10.1021/acsabm.1c00013
ISSN2576-6422
Publisher versionhttps://pubs.acs.org/doi/pdf/10.1021/acsabm.1c00013
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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