Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/70371
Título: | Neurotherapeutic effect of Hyptis spp. leaf extracts in Caenorhabditis elegans models of tauopathy and polyglutamine disease: role of the glutathione redox cycle |
Autor(es): | Vilasboas-Campos, Daniela Costa, Marta Daniela Araújo Castro, Andreia Cristiana Teixeira Rios, Rejaine Silva, Fabiano Guimarães Bessa, Carlos Dias, Alberto Carlos Pires Maciel, P. |
Palavras-chave: | Hyptis spp. Neuroprotection Antioxidant Glutathione reductase Machado-Joseph disease/Spinocerebellar ataxia type 3 Tauopathies |
Data: | 2021 |
Editora: | Elsevier 1 |
Revista: | Free Radical Biology and Medicine |
Citação: | Vilasboas-Campos, Daniela; Costa, Marta Daniela; Teixeira-Castro, Andreia; Rios, Rejaine; Silva, Fabiano Guimarães; Bessa, Carlos; Dias, Alberto; Maciel, Patrícia, Neurotherapeutic effect of Hyptis spp. leaf extracts in Caenorhabditis elegans models of tauopathy and polyglutamine disease: role of the glutathione redox cycle. Free Radical Biology and Medicine, 162, 202-215, 2021. |
Resumo(s): | Hyptis suaveolens (HS), Hyptis pectinata (HP) and Hyptis marrubioides (HM) are plants used in folk medicine for treatment of several diseases. Here, we tested the in vivo antioxidant and neuroprotective potential of methanolic extracts from these plants, containing several rosmarinic acid derivatives and isoquercetin. In C. elegans, HS, HP and HM leaf extracts enhanced the antioxidant responses through the induction of specific antioxidant enzymes and demonstrated neurotherapeutic potential in transgenic models of genetically determined human neurodegenerative diseases - frontotemporal dementia with parkinsonism linked to chromosome 17 and Machado-Joseph disease. Chronic treatment of disease models with HS, HP and HM leaf extracts improved the animals motor function and increased their tolerance to an oxidative insult. The restorative effect of HM extract in motor performance of both disease models required the presence of glutathione reductase (gsr-1), an enzyme that assures the glutathione redox cycle, highlighting the role of this pathway and unveiling a common candidate therapeutic target for these diseases. Our findings strengthen the relevance of plant-derived bioactive compound discovery for neurodegenerative disorders that remain without effective treatment. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/70371 |
DOI: | 10.1016/j.freeradbiomed.2020.10.018 |
ISSN: | 0891-5849 |
Versão da editora: | https://www.journals.elsevier.com/free-radical-biology-and-medicine |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
document_53949_1.pdf Acesso restrito! | 9,32 MB | Adobe PDF | Ver/Abrir |