Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/70370
Título: | The roles of vitamin D and cathelicidin in type 1 diabetes susceptibility |
Autor(es): | Cristelo, Cecília Silva Machado, Fátima Alexandra Meira Sarmento, Bruno Gama, F. M. |
Palavras-chave: | ß cell protection Cathelicidin Diabetes Immunomodulation Vitamin D β cell protection |
Data: | 2021 |
Editora: | Bioscientifica |
Revista: | Endocrine Connections |
Citação: | Cristelo, C.; Machado, A.; Sarmento, Bruno; Gama, F. M., The roles of vitamin D and cathelicidin on type 1 diabetes susceptibility. Endocrine Connections, 10(1), R1-R12, 2021 |
Resumo(s): | Type 1 diabetes has increasingly greater incidence and prevalence with no cure available. Vitamin D supplementation is well documented to reduce the risk of developing type 1 diabetes. Being involved in the modulation of cathelicidin expression, the question whether cathelicidin may be one of the underlying cause arises. Cathelicidin has been implicated in both the development and the protection against type 1 diabetes by mediating the interplay between the gut microbiome, the immune system and cell function. While its potential on type 1 diabetes treatment seems high, the understanding of its effects is still limited. This review aims to contribute to a more comprehensive understanding of the potential of vitamin D and cathelicidin as adjuvants in type 1 diabetes therapy. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/70370 |
DOI: | 10.1530/EC-20-0484 |
ISSN: | 2049-3614 |
Versão da editora: | https://ec.bioscientifica.com |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_54088_1.pdf | 1,75 MB | Adobe PDF | Ver/Abrir |