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https://hdl.handle.net/1822/70058
Título: | Human-based nanocomposite cryogels for hemostatic and wound healing applications |
Autor(es): | Mendes, Bárbara B. Gomez-Florit, Manuel Randall, Lindsey Babo, Pedro Miguel Sousa Almeida, Raquel Carvalho Ferreira Costa Detamore, Michael S. Domingues, Rui Miguel Andrade Reis, R. L. Gomes, Manuela E. |
Palavras-chave: | Hemostatic Platelet lysate Sponge |
Data: | 2019 |
Editora: | Society for Biomaterials (SFB) |
Revista: | Transactions of The Annual Meeting of The Society for Biomaterials |
Citação: | Mendes B. B., Gómez-Florit M., Randall L., Babo P. S., Costa-Almeida R., Detamore M. S., Domingues R. M. A., Reis R. L., Gomes M. E. Human-based nanocomposite cryogels for hemostatic and wound healing applications, Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, Vol. 40, pp. 597, 15267547, 2019 |
Resumo(s): | In trauma surgery, a fast and effective hemostatic agent is crucial to prevent death. The current used hemostatic sponges are highly effective in stopping the hemorrhages, however they have a limited stability, shape memory, and biological functionality to induce an efficient regenerative healing after injury. Blood derivatives have attracted great attention as an inexpensive milieu of bioactive molecules (e.g., growth factors, cytokines), self-assembling scaffolding proteins (e.g., fibrinogen, fibronectin, vitronectin), and antimicrobial peptides (e.g., platelet factor-4) that have the ability to enhance angiogenesis, stem cell recruitment, and tissue regeneration. Among those, platelet lysate (PL) has attracted great attention as a milieu of supra-physiological doses of biomolecules that can be easily standardized. However, the current PL scaffolds showed limited stability and weak mechanical strength, which severely limits its performance as a bioinstructive and hemostatic biomaterial. Herein, we propose the use of aldehyde-functionalized CNC (a-CNC) that will be crosslinked through reversible Schiff base bonds established with the amine groups of PL proteins to produce a stable hemostatic cryogel for wound healing applications. |
Tipo: | Artigo em ata de conferência |
URI: | https://hdl.handle.net/1822/70058 |
ISBN: | 978-1-5108-8390-1 |
ISSN: | 1526-7547 |
Versão da editora: | https://www.scopus.com/record/display.uri?eid=2-s2.0-85065452250&origin=resultslist# |
Arbitragem científica: | no |
Acesso: | Acesso aberto |
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Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20486-762.pdf | 103,13 kB | Adobe PDF | Ver/Abrir |