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https://hdl.handle.net/1822/69642
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Campo DC | Valor | Idioma |
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dc.contributor.author | Oliveira, Isabel Maria Lopes Matos | por |
dc.contributor.author | Gonçalves, Cristiana | por |
dc.contributor.author | Oliveira, Maria Eduarda Moreira Pinheiro Santos | por |
dc.contributor.author | Simón-Váz, Rosana | por |
dc.contributor.author | da Silva Morais, Alain | por |
dc.contributor.author | González-Fernández, África | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Oliveira, J. M. | por |
dc.date.accessioned | 2021-01-25T11:39:42Z | - |
dc.date.available | 2021-01-25T11:39:42Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.citation | Oliveira I. M., Cristiana G., Oliveira E. P., Rosana S. - V., Silva A. M., África G. - F., Reis R. L., Oliveira J. M. PAMAM Dendrimers Functionalised with an Anti-TNF α Antibody and Chondroitin Sulphate for Treatment of Rheumatoid Arthritis, Materials Science and Engineering: C, pp. 111845, doi:10.1016/j.msec.2020.111845, 2021 | por |
dc.identifier.issn | 0928-4931 | por |
dc.identifier.uri | https://hdl.handle.net/1822/69642 | - |
dc.description | "Available online 6 January 2021" | por |
dc.description.abstract | Rheumatoid arthritis is a chronic autoimmune disease characterised by joint synovial inflammation, along with cartilage and bone tissue destruction. Dendrimers can offer new opportunities as drug delivery systems of molecules of interest. Herein we aimed to develop poly(amidoamine) dendrimers (PAMAM), functionalised with chondroitin sulphate (CS), lined with anti-TNF α antibodies (Abs) to provide anti-inflammatory properties. Physicochemical characterisation demonstrated that anti-TNFα Abs-CS/PAMAM dendrimer NPs were successfully produced. The in vitro studies revealed that CS/PAMAM dendrimer NPs did not affect the ATDC5 and THP-1 cell lines' metabolic activity and proliferation, presenting good cytocompatibility and hemocompatibility. Moreover, anti-TNFα Abs-CS/PAMAM dendrimer NPs showed suitable TNF α capture capacity, making them appealing for new immunotherapies in RA patients. | por |
dc.description.sponsorship | The authors thank the financial support under the Norte2020 project (“NORTE-08-5369-FSE-000044”) and BD/137726/2018/J6 21340zkMF. The FCT distinction attributed to J. M. O. under the Investigator FCT program (number IF/01285/2015) is also greatly acknowledged. C. G. also wished to acknowledge FCT for supporting her research (No. SFRH/BPD/94277/2013). RS and AG-F thank Xunta de Galicia (Grupo de Referencia Competitiva, ED431C 2016041) and Centro de Investigaciones Biom ́edicas (CINBIO), Vigo, Spain, for sup-porting their research. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | NORTE-08-5369-FSE-000044 | por |
dc.relation | BD/137726/2018/J6 21340zkMF | por |
dc.relation | IF/01285/2015 | por |
dc.relation | SFRH/BPD/94277/2013 | por |
dc.rights | openAccess | por |
dc.subject | Rheumatoid arthritis | por |
dc.subject | Inflamed joint | por |
dc.subject | PAMAM dendrimer | por |
dc.subject | Chondroitin sulphate | por |
dc.subject | Anti-TNF α | por |
dc.subject | Polyclonal antibody | por |
dc.title | PAMAM dendrimers functionalised with an anti-TNF α antibody and chondroitin sulphate for treatment of rheumatoid arthritis | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0928493120337644?via%3Dihub | por |
dc.comments | http://3bs.uminho.pt/node/20449 | por |
oaire.citationVolume | 121 | por |
dc.date.updated | 2021-01-14T10:27:17Z | - |
dc.identifier.doi | 10.1016/j.msec.2020.111845 | por |
dc.identifier.pmid | 33579481 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Materials Science and Engineering: C | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20449-1-s2.0-S0928493120337644-main.pdf | 2,37 MB | Adobe PDF | Ver/Abrir |