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Title3D hydrogel mimics of the tumor microenvironment: the interplay among hyaluronic acid, stem cells and cancer cells
Author(s)Amorim, Sara
Costa, Diana Pereira Soares
Pashkuleva, I.
Reis, C. A.
Reis, R. L.
Pires, R. A.
Keywords3D cancer model
Hyaluronic acid
Tumour microenvironment
Issue dateOct-2020
PublisherRoyal Society of Chemistry
JournalBiomaterials Science
CitationAmorim S., Soares da Costa D., Pashkuleva I., Reis C. A., Reis R. L., Pires R. A. 3D hydrogel mimics of the tumor microenvironment: the interplay among hyaluronic acid, stem cells and cancer cells, Biomaterials Science, doi:10.1039/D0BM00843E, 2020
Abstract(s)The present work reports on a 3D model of the tumor microenvironment that contains hyaluronic acid (HA) and alginate, and demonstrates the utility of this model to study the effect of HA size on the crosstalk between cancer cells and mesenchymal stem cells (MSCs). The system incorporates a core that contains HA of specific size (i.e. 6.4, 741 or 1500 kDa) with encapsulated epithelial MKN45 cancer cells and a shell with MSCs that mimic the presence of stem cells next to the tumor site. It was found that short HA (i.e. 6.4 kDa) promotes the invasion of cancer cells from the core to the shell, whereas longer HA (i.e. 741 and 1500 kDa) recruits the MSCs into the core, i.e. the tumor site, where a reduction of the formation of cancer cell aggregates was observed. In summary, the developed 3D model recapitulates some key tumor features related to the effect of HA size on both cancer cell invasiveness and MSC behavior at the tumor site.
Publisher version!divAbstract
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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