Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/67199
Registo completo
Campo DC | Valor | Idioma |
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dc.contributor.author | Frazão, Laura Passos Morgado Franco | por |
dc.contributor.author | Castro, Joana Vieira de | por |
dc.contributor.author | Silva, Cristina Isabel Nogueira | por |
dc.contributor.author | Neves, N. M. | por |
dc.date.accessioned | 2020-10-01T14:11:24Z | - |
dc.date.available | 2020-10-01T14:11:24Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Frazão, L.P.; Vieira de Castro, J.; Nogueira-Silva, C.; Neves, N.M. Decellularized Human Chorion Membrane as a Novel Biomaterial for Tissue Regeneration. Biomolecules 2020, 10, 1208. DOI: 10.3390/biom10091208 | por |
dc.identifier.uri | https://hdl.handle.net/1822/67199 | - |
dc.description.abstract | Although some placenta-derived products are already used for tissue regeneration, the human chorion membrane (HCM) alone has been poorly explored. In fact, just one study uses decellularized HCM (dHCM) with native tissue architecture (i.e., without extracellular matrix (ECM) suspension creation) as a substrate for cell differentiation. The aim of this work is to fully characterize the dHCM for the presence and distribution of cell nuclei, DNA and ECM components. Moreover, mechanical properties, in vitro biological performance and in vivo biocompatibility were also studied. Our results demonstrated that the HCM was successfully decellularized and the main ECM proteins were preserved. The dHCM has two different surfaces, the reticular layer side and the trophoblast side; and is biocompatible both in vitro and in vivo. Importantly, the in vivo experiments demonstrated that on day 28 the dHCM starts to be integrated by the host tissue. Altogether, these results support the hypothesis that dHCM may be used as a biomaterial for different tissue regeneration strategies, particularly when a membrane is needed to separate tissues, organs or other biologic compartments. | por |
dc.description.sponsorship | This research was funded by the Portuguese Foundation for Science and Technology (FCT), grant number PD/BD/128103/2016 and FSE/POCH/PD/169/2013 and by the European Regional Development Fund(ERDF), grant number NORTE-01-0145-FEDER-0000232. | por |
dc.language.iso | eng | por |
dc.publisher | Multidisciplinary Digital Publishing Institute | por |
dc.relation | PD/BD/128103/2016 | por |
dc.relation | FSE/POCH/PD/169/2013 | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | chorion membrane | por |
dc.subject | decellularization | por |
dc.subject | extracellular matrix | por |
dc.subject | biocompatible | por |
dc.subject | tissue regeneration | por |
dc.title | Decellularized human chorion membrane as a novel biomaterial for tissue regeneration | eng |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | https://www.mdpi.com/2218-273X/10/9/1208 | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 16 | por |
oaire.citationIssue | 9 | por |
oaire.citationVolume | 10 | por |
dc.date.updated | 2020-09-25T13:27:21Z | - |
dc.identifier.eissn | 2218-273X | - |
dc.identifier.doi | 10.3390/biom10091208 | por |
dc.identifier.pmid | 32825287 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Biomolecules | por |
oaire.version | VoR | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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biomolecules-10-01208.pdf | 5,42 MB | Adobe PDF | Ver/Abrir |
Este trabalho está licenciado sob uma Licença Creative Commons