Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/66386

TitleBactericidal nanopatterns generated by block copolymer self-assembly
Author(s)Fontelo, R.
Soares da Costa, D.
Reis, R. L.
Novoa-Carballal, R.
Pashkuleva, I.
KeywordsAntibacterial polymer surfaces
block copolymers
cell adhesion
Nanopatterns
PS-b-P2VP
Issue dateJun-2020
PublisherElsevier
JournalActa Biomaterialia
CitationFontelo R., Soares da Costa D., Reis R. L., Novoa-Carballal R., Pashkuleva I. Bactericidal nanopatterns generated by block copolymer self-assembly, Acta Biomaterialia, Vol. 112, pp. 174-181, doi:10.1016/j.actbio.2020.06.003, 2020
Abstract(s)We describe the bactericidal capacity of nanopatterned surfaces created by self-assembly of block copolymers. Distinct nanotopographies were generated by spin-coating with polystyrene-block-poly(2-vinylpyridine) (PS-b-P2VP) followed by solvent vapor annealing. We demonstrate that the bactericidal efficiency of the developed coatings depends on the morphology and the chemistry of the surface: cylindrical nanotopographies presenting both blocks at the surface have stronger bactericidal effect on Escherichia coli than micellar patterns with only PS exposed at the surface. The identified mechanism of bacterial death is a mechanical stress exerted by the nanostructures on the cell-wall. Moreover, the developed nanopatterns are not cytotoxic, which makes them an excellent option for coating of implantable materials and devices. The proposed approach represents an efficient tool in the fight against bacteria, which acts via compromising the bacterial wall integrity.
TypeArticle
URIhttp://hdl.handle.net/1822/66386
DOI10.1016/j.actbio.2020.06.003
ISSN1878-7568
Publisher versionhttps://www.sciencedirect.com/science/article/pii/S174270612030324X
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

Files in This Item:
File Description SizeFormat 
20303-Fontelo et al_ActaBiomat_2020.pdf
  Restricted access
1,16 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID