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https://hdl.handle.net/1822/66379
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Campo DC | Valor | Idioma |
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dc.contributor.author | Casanova, Marta Alexandra Rodrigues | por |
dc.contributor.author | Reis, R. L. | por |
dc.contributor.author | Martins, Albino | por |
dc.contributor.author | Neves, N. M. | por |
dc.date.accessioned | 2020-08-07T08:45:03Z | - |
dc.date.issued | 2020-05 | - |
dc.date.submitted | 2020-07 | - |
dc.identifier.citation | Casanova M. R., Reis R. L., Martins A., Neves N. M. Surface biofunctionalization to improve the efficacy of biomaterial substrates to be used in regenerative medicine, Materials Horizons, pp. 1-18, doi:10.1039/D0MH00542H, 2020 | por |
dc.identifier.issn | 2051-6347 | por |
dc.identifier.uri | https://hdl.handle.net/1822/66379 | - |
dc.description.abstract | Surface biofunctionalization has emerged in the past decade as a rising tool in Tissue Engineering and Regenerative Medicine (TERM) approaches. The development of biomaterial substrates with regenerative properties is challenging, mainly due to the requirement of obtaining a surface that promotes cell attachment, proliferation and differentiation. Biomolecules, namely extracellular matrix proteins and growth factors, play a key role in the wound healing cascade, mediating a wide range of cellular activities. Therefore, the immobilization of such biomolecules at the surface of biomaterials has a remarkable interest for TERM strategies. Numerous variants can be used to biofunctionalize the surface of biomaterials, being classified as non-covalent and covalent immobilization strategies. Importantly, the maintenance of stable/available bioactive factors needs also to be considered. In this review, a wide range of bioactive molecules and different biofunctionalization strategies will be discussed, as well as the most relevant results achieved in the novel and most promising strategies. | por |
dc.description.sponsorship | The authors would like to acknowledge the PortugueseFoundation for Science and Technology (FCT) for the PhD grant of M.R.C. (PD/BD/113797/2015) financed by the FCT DoctoralProgram onAdvancedTherapies forHealth (PATH) (FSE/POCH/PD/169/2013), the IF grant of A.M. (IF/00376/2014), and the projects SPARTAN (PTDC/CTM-BIO/4388/2014) andFRONthera(NORTE-01-0145-FEDER-0000232). | por |
dc.language.iso | eng | por |
dc.publisher | Royal Society of Chemistry | por |
dc.relation | The authors would like to acknowledge the Portuguese Foundation for Science and Technology (FCT) for the PhD grant of M.R.C. (PD/BD/113797/2015) financed by the FCT DoctoralProgram on Advanced Therapies for Health (PATH) (FSE/POCH/PD/169/2013), the IF grant of A.M. (IF/00376/2014), and the projects SPARTAN (PTDC/CTM-BIO/4388/2014) and FRONthera (NORTE-01-0145-FEDER-0000232). | - |
dc.relation | PTDC/CTM-BIO/4388/2014 | - |
dc.rights | restrictedAccess | por |
dc.subject | Bioactive molecules | por |
dc.subject | Biomaterials Substrate | por |
dc.subject | Growth factors | por |
dc.subject | Surface functionalization | por |
dc.subject | Surface Immobilization | por |
dc.subject | Tissue engineering and regenerative medicine | por |
dc.title | Surface biofunctionalization to improve the efficacy of biomaterial substrates to be used in regenerative medicine | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://dx.doi.org/10.1039/D0MH00542H | por |
dc.comments | http://3bs.uminho.pt/node/20326 | por |
oaire.citationStartPage | 2258 | por |
oaire.citationEndPage | 2275 | por |
oaire.citationIssue | 9 | por |
oaire.citationVolume | 7 | por |
dc.date.updated | 2020-08-06T14:22:26Z | - |
dc.identifier.eissn | 2051-6355 | por |
dc.identifier.doi | 10.1039/D0MH00542H | por |
dc.date.embargo | 10000-01-01 | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | Materials Horizons | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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20326-10.1039@D0MH00542H(1).pdf Acesso restrito! | 1,42 MB | Adobe PDF | Ver/Abrir |