Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/66212
Título: | Adapting to survive: How Candida overcomes host-imposed constraints during human colonization |
Autor(es): | Alves, Rosana Barata-Antunes, Claudia Casal, Margarida Brown, Alistair J. P. Van Dijck, Patrick Paiva, Sandra |
Data: | 2020 |
Editora: | Public Library of Science |
Revista: | PLoS Pathogens |
Resumo(s): | Successful human colonizers such as Candida pathogens have evolved distinct strategies to survive and proliferate within the human host. These include sophisticated mechanisms to evade immune surveillance and adapt to constantly changing host microenvironments where nutrient limitation, pH fluctuations, oxygen deprivation, changes in temperature, or exposure to oxidative, nitrosative, and cationic stresses may occur. Here, we review the current knowledge and recent findings highlighting the remarkable ability of medically important Candida species to overcome a broad range of host-imposed constraints and how this directly affects their physiology and pathogenicity. We also consider the impact of these adaptation mechanisms on immune recognition, biofilm formation, and antifungal drug resistance, as these pathogens often exploit specific host constraints to establish a successful infection. Recent studies of adaptive responses to physiological niches have improved our understanding of the mechanisms established by fungal pathogens to evade the immune system and colonize the host, which may facilitate the design of innovative diagnostic tests and therapeutic approaches for Candida infections. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/66212 |
DOI: | 10.1371/journal.ppat.1008478 |
ISSN: | 1553-7366 |
Versão da editora: | https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008478 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | DBio - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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2020-A-96. Plos Pathogene- adapting to survive.pdf | 2,31 MB | Adobe PDF | Ver/Abrir |