Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/66212

TitleAdapting to survive: How Candida overcomes host-imposed constraints during human colonization
Author(s)Alves, Rosana
Barata-Antunes, Claudia
Casal, Margarida
Brown, Alistair J. P.
Van Dijck, Patrick
Paiva, Sandra
Issue date2020
PublisherPublic Library of Science
JournalPLoS Pathogens
Abstract(s)Successful human colonizers such as Candida pathogens have evolved distinct strategies to survive and proliferate within the human host. These include sophisticated mechanisms to evade immune surveillance and adapt to constantly changing host microenvironments where nutrient limitation, pH fluctuations, oxygen deprivation, changes in temperature, or exposure to oxidative, nitrosative, and cationic stresses may occur. Here, we review the current knowledge and recent findings highlighting the remarkable ability of medically important Candida species to overcome a broad range of host-imposed constraints and how this directly affects their physiology and pathogenicity. We also consider the impact of these adaptation mechanisms on immune recognition, biofilm formation, and antifungal drug resistance, as these pathogens often exploit specific host constraints to establish a successful infection. Recent studies of adaptive responses to physiological niches have improved our understanding of the mechanisms established by fungal pathogens to evade the immune system and colonize the host, which may facilitate the design of innovative diagnostic tests and therapeutic approaches for Candida infections.
TypeArticle
URIhttp://hdl.handle.net/1822/66212
DOI10.1371/journal.ppat.1008478
ISSN1553-7366
Publisher versionhttps://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008478
Peer-Reviewedyes
AccessOpen access
Appears in Collections:DBio - Artigos/Papers

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