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TitlePopulation analysis and evolution of Saccharomyces cerevisiae mitogenomes
Author(s)Vieira, Daniel
Esteves, Soraia
Santiago, Carolina
Conde-Sousa, Eduardo
Fernandes, Ticiana
Pais, Célia
Soares, Pedro
Franco-Duarte, Ricardo
Keywordsmitochondrial genome
Saccharomyces cerevisiae
genomic characterization
Issue date2020
PublisherMultidisciplinary Digital Publishing Institute
CitationVieira, D.; Esteves, S.; Santiago, C.; Conde-Sousa, E.; Fernandes, T.; Pais, C.; Soares, P.; Franco-Duarte, R. Population Analysis and Evolution of Saccharomyces cerevisiae Mitogenomes. Microorganisms 2020, 8, 1001.
Abstract(s)The study of mitogenomes allows the unraveling of some paths of yeast evolution that are often not exposed when analyzing the nuclear genome. Although both nuclear and mitochondrial genomes are known to determine phenotypic diversity and fitness, no concordance has yet established between the two, mainly regarding strains’ technological uses and/or geographical distribution. In the current work, we proposed a new method to align and analyze yeast mitogenomes, overcoming current difficulties that make it impossible to obtain comparable mitogenomes for a large number of isolates. To this end, 12,016 mitogenomes were considered, and we developed a novel approach consisting of the design of a reference sequence intended to be comparable between all mitogenomes. Subsequently, the population structure of 6646 <i>Saccharomyces cerevisiae</i> mitogenomes was assessed. Results revealed the existence of particular clusters associated with the technological use of the strains, in particular regarding clinical isolates, laboratory strains, and yeasts used for wine-associated activities. As far as we know, this is the first time that a positive concordance between nuclear and mitogenomes has been reported for <i>S. cerevisiae</i>, in terms of strains’ technological applications. The results obtained highlighted the importance of including the mtDNA genome in evolutionary analysis, in order to clarify the origin and history of yeast species.
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AccessOpen access
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