Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/65624
Título: | Current advances in the development of novel polymeric nanoparticles for the treatment of neurodegenerative diseases |
Autor(es): | Cano, Amanda Sánchez-López, Elena Ettcheto, Miren López-Machado, Ana Espina, Marta Souto, Eliana B. Galindo, Ruth Camins, Antonio García, Maria Luisa Turowski, Patric |
Palavras-chave: | brain disorders brain targeting CNS nanomedicine neurodegenerative diseases neurological diseases polymeric nanoparticles |
Data: | 2020 |
Editora: | Future Medicine |
Revista: | Nanomedicine |
Citação: | Cano, Amanda; Sánchez-López, Elena; Ettcheto, Miren; López-Machado, Ana; Espina, Marta; Souto, Eliana; Galindo, Ruth; Camins, Antonio; García, Maria Luisa; Turowski, Patric, Current advances in the development of novel polymeric nanoparticles for the treatment of neurodegenerative diseases. Nanomedicine, 15(12), 2020 |
Resumo(s): | Effective intervention is essential to combat the coming epidemic of neurodegenerative (ND) diseases. Nanomedicine can overcome restrictions of CNS delivery imposed by the bloodbrain barrier, and thus be instrumental in preclinical discovery and therapeutic intervention of ND diseases. Polymeric nanoparticles (PNPs) have shown great potential and versatility to encapsulate several compounds simultaneously in controlled drug-delivery systems and target them to the deepest brain regions. Here, we critically review recent advances in the development of drugs incorporated into PNPs and summarize the molecular changes and functional effects achieved in preclinical models of the most common ND disorders. We also briefly discuss the many challenges remaining to translate these findings and technological advances successfully to current clinical settings. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/65624 |
DOI: | 10.2217/nnm-2019-0443 |
ISSN: | 1743-5889 |
e-ISSN: | 1748-6963 |
Versão da editora: | https://www.futuremedicine.com/journal/nnm |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_53669_1.pdf Acesso restrito! | 7,54 MB | Adobe PDF | Ver/Abrir |