Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/64955

TítuloMicrofuidic devices and three dimensional-printing strategies for in vitro models of bone
Autor(es)Maia, F. Raquel
Reis, R. L.
Correlo, V. M.
Oliveira, Joaquim M.
Palavras-chaveBone Tissue Engineering
Microfluidic devices
Three-dimensional models
Bioprinting
In vitro models
DataAbr-2020
EditoraSpringer Nature
RevistaAdvances in Experimental Medicine and Biology
CitaçãoMaia F. R., Reis R. L., Correlo V. M., Oliveira J. M. Microfluidic Devices and Three Dimensional-Printing Strategies for in vitro Models of Bone, Biomaterials- and Microfluidics-Based Tissue Engineered 3D Models, Vol. 1230, pp. 1-14, doi:https://doi.org/10.1007/978-3-030-36588-2_1, 2020
Resumo(s)Bone is a complex and highly dynamic tissue, which has been worldwide studied, from fundamental biology to tissue engineering fields. Even so, current in vitro models do not truly replicate the native bone tissue environment. For so, new and improved in vitro tissue models are necessary to obtain more reliable data, not only in a development point of view, but also to fasten the translation of new drugs into the clinics. In this reasoning, tissue-engineering strategies were applied to develop mimetic and three-dimensional (3D) microenvironments, which were associated with microfluidic devices for the development of more complex and realistic systems. Such devices mimic blood vessels that are present in the native tissue, thus enabling the study of complex biological mechanism as such as bone angiogenesis. More recently, 3D printing has been pursued to produce more intricate microfluidic devices and engineered tissues in a single step. The ability to print spatially controlled structures composed of different biomaterials, growth factors and cells caught the attention of scientists for the development of more efficient in vitro models. Additionally, it allows obtaining microfluidic devices and/or engineered tissues with the desired architecture within a small amount of time and with reduced costs. Recently, the use of high-resolution scanning boosted the production of patient-specific implants. Despite the difficulties associated with 3D printed structures that still need to be overcome, it has been proven to be a valuable tool to accomplish a new generation of 3D bioprinted bone-on-a-chip platforms.
TipoCapítulo de livro
URIhttps://hdl.handle.net/1822/64955
ISBN978-3-030-36588-2
DOI10.1007/978-3-030-36588-2_1
ISSN0065-2598
Versão da editorahttps://link.springer.com/chapter/10.1007/978-3-030-36588-2_1
AcessoAcesso restrito UMinho
Aparece nas coleções:3B’s - Capítulos de Livros/Book Chapters

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